3-Pyridazinecarboxaldehyde, 6-chloro- (9CI)

Base Information

• Chemical Name: 3-Pyridazinecarboxaldehyde, 6-chloro- (9CI)
• CAS No.: 303085-53-2
• Molecular Formula: C5H3ClN2O
• Molecular Weight: 142.545
• Hs Code.: 2933990090
• Mol file: 303085-53-2.mol

Synonyms:6-Chloro-3-pyridazinecarboxaldehyde;6-chloropyridazine-3-carbaldehyde;3-pyridazinecarboxaldehyde, 6-chloro-;

Chemical Property of 3-Pyridazinecarboxaldehyde, 6-chloro- (9CI)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.601
• Boiling Point: 334.621 °C at 760 mmHg
• PKA: -0.81±0.10(Predicted)
• Flash Point: 156.174 °C
• PSA: 42.85000
• Density: 1.433 g/cm³
• LogP: 0.94250
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Chloropyridazine-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-chloropyridazine-3-carbaldehyde is a useful reactant for organic synthesis.

Technology Process of 3-Pyridazinecarboxaldehyde, 6-chloro- (9CI)

There total 6 articles about 3-Pyridazinecarboxaldehyde, 6-chloro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

6-chloro-3-pyridazinecarboxylic acid ethyl ester (75680-92-1) → 6-chloro-3-pyridazinecarboxaldehyde (303085-53-2)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

Reference yield: 52.0%

methyl 6-chloro-3-pyridazinecarboxylate (65202-50-8) → 6-chloro-3-pyridazinecarboxaldehyde (303085-53-2)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

Reference yield: 50.1%

C7H8ClN3O2 → 6-chloro-3-pyridazinecarboxaldehyde (303085-53-2)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

upstream raw materials:

6-chloro-3-pyridazinecarboxylic acid ethyl ester

3-chloro-6-vinylpyridazine

methyl 6-chloro-3-pyridazinecarboxylate

6-chloro-pyridazine-3-carboxylic acid

Downstream raw materials:

6-chloro-pyridazine-3-carboxylic acid

3-chloro-6-(difluoromethyl)pyridazine

(6-chloropyridazin-3-yl)methanol

Refernces

• 1、 -. "TETRAHYDROPYRAZOLO-PYRAZINYL-DIHYDROIMIDAZOLONE OR TETRAHYDROPYRAZOLO-PYRIDINYL-DIHYDROIMIDAZOLONE COMPOUNDS AND METHODS OF USING SAME". . . Retrieved 2022/02/05.
• 2、 -. "BENZAMIDE CGRP RECEPTOR ANTAGONISTS". Page/Page column 120. . Retrieved 2015/11/09.