2-Methyl-1,8-naphthyridine-3-carboxylic acid

Base Information

• Chemical Name: 2-Methyl-1,8-naphthyridine-3-carboxylic acid
• CAS No.: 387350-60-9
• Molecular Formula: C10H10N2O3
• Molecular Weight: 188.186
• Hs Code.: 2933990090
• European Community (EC) Number: 674-415-6
• DSSTox Substance ID: DTXSID90371695
• Nikkaji Number: J3.343.447B
• Wikidata: Q72493302
• Mol file: 387350-60-9.mol

Synonyms:2-methyl-1,8-naphthyridine-3-carboxylic acid;387350-60-9;Peakdale1_000001;SCHEMBL125290;HMS518A01;DTXSID90371695;STQOBEMCYUGNTL-UHFFFAOYSA-N;MFCD00202882;AKOS006227664;PS-5304;AC-23818;CS-0059252;FT-0687340;E75221;EN300-179588;A824253;Z1198151998

Chemical Property of 2-Methyl-1,8-naphthyridine-3-carboxylic acid

Chemical Property:

• Vapor Pressure: 1.08E-05mmHg at 25°C
• Melting Point: 191-195 °C
• Refractive Index: 1.673
• Boiling Point: 356.3 °C at 760 mmHg
• PKA: 1.33±0.30(Predicted)
• Flash Point: 169.3 °C
• PSA: 63.08000
• Density: 1.355 g/cm³
• LogP: 1.63640
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 188.058577502
• Heavy Atom Count: 14
• Complexity: 232

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-1,8-naphthyridine-3-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=C2C=CC=NC2=N1)C(=O)O

Technology Process of 2-Methyl-1,8-naphthyridine-3-carboxylic acid

There total 3 articles about 2-Methyl-1,8-naphthyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-Aminonicotinaldehyde (7521-41-7) + acetoacetic acid methyl ester (105-45-3) → 2-methyl-1,8-naphthyridine-3-carboxylic acid (387350-60-9)

Guidance literature:

In toluene; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tetlet.2014.04.010

Reference yield: 60.0%

2-methyl-1,8-naphthyridine-3-carboxylic acid ethyl ester (5174-88-9) → 2-methyl-1,8-naphthyridine-3-carboxylic acid (387350-60-9)

Guidance literature:

With potassium hydroxide; In ethanol; water; for 4h; Heating;

Reference yield:

→ 2-methyl-1,8-naphthyridine-3-carboxylic acid (387350-60-9)

Guidance literature:

upstream raw materials:

2-methyl-1,8-naphthyridine-3-carboxylic acid ethyl ester

2-Aminonicotinaldehyde

acetoacetic acid methyl ester

Downstream raw materials:

N-(1-(4'-methoxybiphenyl-4-yl)ethyl)-2-methyl-1,8-naphthyridine-3-carboxamide

2-methyl-N-(1-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)ethyl)-1,8-naphthyridine-3-carboxamide

N-(4-(1-hydroxycyclohexyl)benzyl)-2-methyl-1,8-naphthyridine-3-carboxamide

2-methyl-N-(2-(trifluoromethyl)benzyl)-1,8-naphthyridine-3-carboxamide

Refernces

• 1、 Ramesh,Thirumala Chary,Laxminarayana,Sreenivasulud. "Synthesis and antimicrobial activity of 1-alkyl and aryl-3-(2-methyl-l,8- naphthyridin-3 -yl)ureas". scheme or table. p. 1271 - 1273. Retrieved 2010/12/20.
• 2、 Ramesh,Sreenivasulu. "Synthesis and biological activity of esters of 2-methyl-1,8-naphthyridine-3-carbamic acid". . p. 897 - 900. Retrieved 2007/10/03.