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7521-41-7 Usage

Chemical Properties

yellow crystals

Uses

2-Aminonicotinaldehyde is commonly employed as a starting material for a wide variety of N-heterocyclic compounds (e.g. β-nicotyrine [N445000]) . 2-Aminonicotinaldehyde is also used as a reagent to synthesize hydrazones (e.g.thionaphthenquinone 3-hydrazone [T367720]), which possess antituburcular properties.

Check Digit Verification of cas no

The CAS Registry Mumber 7521-41-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,5,2 and 1 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 7521-41:
(6*7)+(5*5)+(4*2)+(3*1)+(2*4)+(1*1)=87
87 % 10 = 7
So 7521-41-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H6N2O/c7-6-5(4-9)2-1-3-8-6/h1-4H,(H2,7,8)/p+1

7521-41-7 Well-known Company Product Price

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  • (Code)Product description
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  • Detail
  • Alfa Aesar

  • (L19620)  2-Aminopyridine-3-carboxaldehyde, 98%   

  • 7521-41-7

  • 1g

  • 473.0CNY

  • Detail
  • Alfa Aesar

  • (L19620)  2-Aminopyridine-3-carboxaldehyde, 98%   

  • 7521-41-7

  • 5g

  • 1577.0CNY

  • Detail
  • Aldrich

  • (639109)  2-Amino-3-pyridinecarboxaldehyde  97%

  • 7521-41-7

  • 639109-1G

  • 1,198.08CNY

  • Detail
  • Aldrich

  • (639109)  2-Amino-3-pyridinecarboxaldehyde  97%

  • 7521-41-7

  • 639109-5G

  • 4,130.10CNY

  • Detail

7521-41-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Amino-3-pyridinecarboxaldehyde

1.2 Other means of identification

Product number -
Other names 2-aminopyridine-3-carbaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7521-41-7 SDS

7521-41-7Synthetic route

N-(3-formyl-2-pyridinyl)-2,2-dimethylpropanamide
86847-64-5

N-(3-formyl-2-pyridinyl)-2,2-dimethylpropanamide

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
Stage #1: N-(3-formyl-2-pyridinyl)-2,2-dimethylpropanamide With hydrogenchloride In water for 18h; Heating / reflux;
Stage #2: With potassium carbonate In water at 20℃; pH=7;
100%
With hydrogenchloride for 4h; Heating;93%
With hydrogenchloride In water
2-(pivaloylamino)pyridine
86847-59-8

2-(pivaloylamino)pyridine

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
Multistep reaction;84%
(2-amino-3-pyridinyl)methanol
23612-57-9

(2-amino-3-pyridinyl)methanol

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
With manganese(IV) oxide In dichloromethane at 20℃;83%
With manganese(IV) oxide In dichloromethane at 20℃;83%
With manganese(IV) oxide In dichloromethane at 20℃; for 18h;
2-<3-(dibromomethyl)-2-pyridinyl>-1H-isoindole-1,3(2H)-dione
114858-36-5

2-<3-(dibromomethyl)-2-pyridinyl>-1H-isoindole-1,3(2H)-dione

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
Stage #1: 2-<3-(dibromomethyl)-2-pyridinyl>-1H-isoindole-1,3(2H)-dione With ammonia In ethanol; water at 4 - 20℃; for 1.16667h;
Stage #2: With hydrogenchloride In water for 3h; Heating / reflux;
70%
Multi-step reaction with 2 steps
1: NH4OH / ethanol
2: 65 percent / HCl(conc) / 3 h / Heating
View Scheme
2-(3-Iminomethyl-pyridin-2-yl)-isoindole-1,3-dione
114858-37-6

2-(3-Iminomethyl-pyridin-2-yl)-isoindole-1,3-dione

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
With hydrogenchloride for 3h; Heating;65%
2-tert-butylamino-pyridine-3-carbaldehyde
855313-30-3

2-tert-butylamino-pyridine-3-carbaldehyde

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
With hydrogenchloride52%
3-cyano-1-methylpyridinium iodide
1004-16-6

3-cyano-1-methylpyridinium iodide

A

pyridine-3-carbonitrile
100-54-9

pyridine-3-carbonitrile

B

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

C

2-methylamino-3-pyridinecarboxaldehyde
32399-08-9

2-methylamino-3-pyridinecarboxaldehyde

Conditions
ConditionsYield
With ammonium hydroxide at 180℃; for 35h;A 45%
B 6%
C 8%
2--3-pyridinecarboxaldehyde
116026-94-9

2--3-pyridinecarboxaldehyde

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; Inert atmosphere;40%
2-(3-pyridyl)-1,3,8-triazanaphthalene
7521-27-9

2-(3-pyridyl)-1,3,8-triazanaphthalene

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
With hydrogenchloride In water for 1h;38%
With hydrogenchloride at 100℃;38%
With hydrogenchloride In water for 4h; Reflux; Inert atmosphere;30%
nicotinamide
98-92-0

nicotinamide

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
Stage #1: nicotinamide With ammonium sulfamate at 150 - 200℃; for 9h;
Stage #2: With ammonia In water for 1h;
Stage #3: With hydrogenchloride for 4h; Heating;
11%
Multi-step reaction with 2 steps
1: ammonium sulfamate / 11 h / 150 - 200 °C
2: 2 N HCl, water / 4 h / Heating
View Scheme
Stage #1: nicotinamide With hydrogenchloride; ammonium sulphamate In water
Stage #2: With sodium hydroxide
2-amino-nicotinic acid isopropylidenehydrazide

2-amino-nicotinic acid isopropylidenehydrazide

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
With ammonium hydroxide; sodium periodate
N-[4-(2-amino-[3]pyridyl)-but-3-enyl]-N-methyl-acetamide

N-[4-(2-amino-[3]pyridyl)-but-3-enyl]-N-methyl-acetamide

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
With hydrogenchloride; ozone
pyridine-3-carbonitrile
100-54-9

pyridine-3-carbonitrile

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
With hydrogenchloride; water for 4h; Heating; Yield given;
2-aminopyridine
504-29-0

2-aminopyridine

ethyl halide

ethyl halide

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 67 percent / DIEA / CH2Cl2
2: 95 percent / LDA
3: 52 percent / aq. HCl
View Scheme
N-tert-butyl-2-aminopyridine
76293-30-6

N-tert-butyl-2-aminopyridine

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / LDA
2: 52 percent / aq. HCl
View Scheme
2-aminopyridine
504-29-0

2-aminopyridine

Fmoc-L-Tyr(OtBu)-Wang resin

Fmoc-L-Tyr(OtBu)-Wang resin

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 94 percent / Et3N / various solvent(s) / 2 h / 20 °C
View Scheme
3-methylpyridin-2-ylamine
1603-40-3

3-methylpyridin-2-ylamine

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 93 percent / 190 °C
2: 86.6 percent / NBS, AIBN / CCl4 / Heating
3: NH4OH / ethanol
4: 65 percent / HCl(conc) / 3 h / Heating
View Scheme
2-(3-methyl-2-pyridinyl)-1H-isoindole-1,3(2H)-dione
64959-77-9

2-(3-methyl-2-pyridinyl)-1H-isoindole-1,3(2H)-dione

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 86.6 percent / NBS, AIBN / CCl4 / Heating
2: NH4OH / ethanol
3: 65 percent / HCl(conc) / 3 h / Heating
View Scheme
2-aminopyridine
504-29-0

2-aminopyridine

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 79 percent / triethylamine / CH2Cl2 / 2 h / Ambient temperature
2: 1) n-BuLi, 2) 6 N HCl / THF, hexane 1.) 0 degC, 4h, 2) -78 deg C to room temp.
3: 93 percent / 3 N aqueous HCl / 4 h / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: tert-butyl alcohol / 30 - 40 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
2.2: -78 - -20 °C / Inert atmosphere
2.3: -78 - 20 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: triethylamine
2: n-butyllithium
3: hydrogenchloride / water
View Scheme
2-(pivaloylamino)pyridine
86847-59-8

2-(pivaloylamino)pyridine

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1) n-BuLi, 2) 6 N HCl / THF, hexane 1.) 0 degC, 4h, 2) -78 deg C to room temp.
2: 93 percent / 3 N aqueous HCl / 4 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: n-butyllithium
2: hydrogenchloride / water
View Scheme
2-aminonicotinic acid hydrazide
5327-31-1

2-aminonicotinic acid hydrazide

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: aqueous NH3; NaIO4
View Scheme
N-(tert-butoxycarbonyl)-2-aminopyridine
38427-94-0

N-(tert-butoxycarbonyl)-2-aminopyridine

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
1.2: -78 - -20 °C / Inert atmosphere
1.3: -78 - 20 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere
View Scheme
2-Nitro-nicotinaldehyd
5175-26-8

2-Nitro-nicotinaldehyd

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
With hydrogenchloride
2-(3'-pyridyl)pyrido[2,3-d]pyrimidine
1035796-03-2

2-(3'-pyridyl)pyrido[2,3-d]pyrimidine

2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Conditions
ConditionsYield
With hydrogenchloride for 8h; Reflux;
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

cyanoacetic acid amide
107-91-5

cyanoacetic acid amide

2-Amino-1,8-naphthyridine-3-carboxamide
15935-96-3

2-Amino-1,8-naphthyridine-3-carboxamide

Conditions
ConditionsYield
With piperidine at 20℃; for 0.166667h; Friedlander condensation;100%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

malonodiamide
108-13-4

malonodiamide

2-Amino-1,8-naphthyridine-3-carboxamide
15935-96-3

2-Amino-1,8-naphthyridine-3-carboxamide

Conditions
ConditionsYield
With piperidine In methanol for 0.0333333h; Friedlander condensation; microwave irradiation;100%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

cyclopentanone
120-92-3

cyclopentanone

7,8-dihydro-6H-cyclopenta[b]-1,8-naphthyridine
58309-27-6

7,8-dihydro-6H-cyclopenta[b]-1,8-naphthyridine

Conditions
ConditionsYield
With ytterbium(III) triflate at 20℃; for 1h; Friedlaender reaction;100%
With 1-butyl-3-methylimidazolium methoxide at 70℃; for 23h; Inert atmosphere;90%
With sodium hydrogensulfate on silicagel In neat (no solvent) at 80℃; for 0.533333h; Friedlaender Quinoline Synthesis; Green chemistry;85%
With Poly(2-acrylamido-2-methylpropanesulfonic acid-co-acrylic acid) In neat (no solvent) at 110℃; for 0.666667h; Friedlaender Quinoline Synthesis; Green chemistry;82%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

acetone
67-64-1

acetone

2-methyl-[1,8]naphthyridine
1569-16-0

2-methyl-[1,8]naphthyridine

Conditions
ConditionsYield
With L-proline99%
With L-proline In ethanol for 16h; Reflux;99%
With L-proline In ethanol Reflux;99%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

pyruvic acid methyl ester
600-22-6

pyruvic acid methyl ester

1,8-naphthyridine-2-carboxylic acid
215523-34-5

1,8-naphthyridine-2-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 20℃; for 16h; Cooling;99%
With water; sodium hydroxide In ethanol at 0 - 20℃; for 18h;
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

o-hydroxyacetophenone
118-93-4

o-hydroxyacetophenone

2-(2-hydroxyphenyl)-1,8-naphthyridine
65182-56-1

2-(2-hydroxyphenyl)-1,8-naphthyridine

Conditions
ConditionsYield
With potassium hydroxide In methanol at 65℃; for 7h;98%
With potassium hydroxide for 0.05h; microwave irradiation;90%
With potassium hydroxide In methanol; water at 60℃; Friedlaender Quinoline Synthesis;82%
With sulfuric acid In acetic acid for 3h; Heating;78%
With potassium hydroxide In ethanol for 4h; Heating;
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

N-phenylacetoacetamide
102-01-2

N-phenylacetoacetamide

2-methyl-N-phenyl-1,8-naphthyridine-3-carboxamide
112697-61-7

2-methyl-N-phenyl-1,8-naphthyridine-3-carboxamide

Conditions
ConditionsYield
With lithium chloride for 0.0833333h; Friedlaender condensation; microwave irradiation;98%
With toluene-4-sulfonic acid at 20℃; for 5h; Friedlander condensation;92%
With zirconyl chloride octahydrate In neat (no solvent, solid phase) at 70 - 80℃; for 0.15h;92%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

acetylacetone
123-54-6

acetylacetone

1-(2-methyl-1,8-naphthyridin-3-yl)ethan-1-one
5174-87-8

1-(2-methyl-1,8-naphthyridin-3-yl)ethan-1-one

Conditions
ConditionsYield
With charcoal MgO In neat (no solvent) at 49.84℃; for 1h; Temperature; Friedlaender Quinoline Synthesis; Green chemistry;98%
With piperidine at 20℃; for 0.333333h; Friedlander condensation;96%
With sodium hydrogensulfate on silicagel In neat (no solvent) at 80℃; Solvent; Temperature; Friedlaender Quinoline Synthesis; Green chemistry;96%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

malononitrile
109-77-3

malononitrile

2-amino-3-cyano-1,8-naphthyridine
15935-95-2

2-amino-3-cyano-1,8-naphthyridine

Conditions
ConditionsYield
With piperidine at 20℃; for 0.0333333h; Friedlander condensation;98%
piperidine In ethanol95%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

p-methoxybenzylnitrile
104-47-2

p-methoxybenzylnitrile

2-amino-3-(p-methoxyphenyl)-1,8-naphthyridine
60467-64-3

2-amino-3-(p-methoxyphenyl)-1,8-naphthyridine

Conditions
ConditionsYield
With piperidine at 20℃; for 0.133333h;98%
With potassium hydroxide Microwave irradiation;
With piperidine In neat (no solvent) at 20℃;
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

cyanoacetic acid amide
107-91-5

cyanoacetic acid amide

2-amino-3-cyano-1,8-naphthyridine
15935-95-2

2-amino-3-cyano-1,8-naphthyridine

Conditions
ConditionsYield
With piperidine In methanol for 0.00833333h; Friedlander condensation; microwave irradiation;98%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

1,1′-(pyrazine-2,5-diyl)diethanone
39248-49-2

1,1′-(pyrazine-2,5-diyl)diethanone

2,5-di-(1′,8′-dinaphthyridin-2′-yl)pyrazine

2,5-di-(1′,8′-dinaphthyridin-2′-yl)pyrazine

Conditions
ConditionsYield
With potassium hydroxide In ethanol for 5h; Friedlaender condensation; Heating;98%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

3-chloro-benzeneacetonitrile
1529-41-5

3-chloro-benzeneacetonitrile

2-amino-3-(m-chlorophenyl)-1,8-naphthyridine
756500-63-7

2-amino-3-(m-chlorophenyl)-1,8-naphthyridine

Conditions
ConditionsYield
With potassium hydroxide for 0.0333333h; microwave irradiation;98%
With piperidine In neat (no solvent) Milling; Green chemistry;
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Cyclopropyl methyl ketone
765-43-5

Cyclopropyl methyl ketone

2-(cyclopropyl)-1,8-naphthyridine

2-(cyclopropyl)-1,8-naphthyridine

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water for 1h; Friedlaender reaction; Heating;98%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

2-Chlorophenylacetonitrile
2856-63-5

2-Chlorophenylacetonitrile

2-amino-3-(o-chlorophenyl)-1,8-naphthyridine
845533-60-0

2-amino-3-(o-chlorophenyl)-1,8-naphthyridine

Conditions
ConditionsYield
With sodium hydroxide for 0.0333333h; microwave irradiation;98%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

4-Bromophenylacetonitrile
16532-79-9

4-Bromophenylacetonitrile

2-amino-3-(p-bromophenyl)-1,8-naphthyridine
883564-47-4

2-amino-3-(p-bromophenyl)-1,8-naphthyridine

Conditions
ConditionsYield
With potassium hydroxide for 0.0416667h; microwave irradiation;98%
With piperidine In neat (no solvent) Milling; Green chemistry;
With piperidine In neat (no solvent) at 20℃;
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

4-Nitrophenylacetonitrile
555-21-5

4-Nitrophenylacetonitrile

2-amino-3-(p-nitrophenyl)-1,8-naphthyridine
60467-62-1

2-amino-3-(p-nitrophenyl)-1,8-naphthyridine

Conditions
ConditionsYield
With potassium hydroxide for 0.025h; microwave irradiation;98%
With piperidine In neat (no solvent) Milling; Green chemistry;
With piperidine In neat (no solvent) at 20℃;
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

7,8,9,10-tetrahydroazepino[2,1-b]quinazoline-6,12-dione

7,8,9,10-tetrahydroazepino[2,1-b]quinazoline-6,12-dione

3,2'-trimethylene-2-(1,8-naphthydrid-2-yl)-4(3H)-quinazolinone

3,2'-trimethylene-2-(1,8-naphthydrid-2-yl)-4(3H)-quinazolinone

Conditions
ConditionsYield
With potassium hydroxide In ethanol Friedlaender condensation; Heating;98%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

2-Acetylthiazole
24295-03-2

2-Acetylthiazole

2-(1,8-naphthyridin-2-yl)thiazole
170439-30-2

2-(1,8-naphthyridin-2-yl)thiazole

Conditions
ConditionsYield
With potassium hydroxide In methanol; water at 60℃;98%
With potassium hydroxide In methanol at 60℃; Inert atmosphere; Schlenk technique; Reflux;82%
With potassium hydroxide In methanol46%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

3-fluorophenylacetonitrile
501-00-8

3-fluorophenylacetonitrile

2-amino-3-(3-fluorophenyl)-1,8-naphthyridine
1082419-13-3

2-amino-3-(3-fluorophenyl)-1,8-naphthyridine

Conditions
ConditionsYield
With potassium hydroxide In water for 0.0416667h; Microwave irradiation;98%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

2-fluorophenyl acetonitrile
326-62-5

2-fluorophenyl acetonitrile

2-amino-3-(2-fluorophenyl)-1,8-naphthyridine
1082583-45-6

2-amino-3-(2-fluorophenyl)-1,8-naphthyridine

Conditions
ConditionsYield
With potassium hydroxide for 0.0333333h; Microwave irradiation; Neat (no solvent);98%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

4-fluorophenylacetonitrile
459-22-3

4-fluorophenylacetonitrile

2-amino-3-(4-fluorophenyl)-1,8-naphthyridine
60467-61-0

2-amino-3-(4-fluorophenyl)-1,8-naphthyridine

Conditions
ConditionsYield
With potassium hydroxide Microwave irradiation;98%
With piperidine In neat (no solvent) Milling; Green chemistry;
With piperidine In neat (no solvent) at 20℃;
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

methyl 3-oxohexanoate
30414-54-1

methyl 3-oxohexanoate

2-propyl-1,8-naphthyridine-3-carboxylic acid
1609489-37-3

2-propyl-1,8-naphthyridine-3-carboxylic acid

Conditions
ConditionsYield
In toluene at 110℃; for 24h; Friedlaender Quinoline Synthesis; Inert atmosphere;98%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

Ethyl 3-cyclopropyl-3-oxopropionate
24922-02-9

Ethyl 3-cyclopropyl-3-oxopropionate

2-cyclopropyl-[1,8]-naphthyridine-3-carboxylic acid ethyl ester
1208990-49-1

2-cyclopropyl-[1,8]-naphthyridine-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydrogensulfate on silicagel In neat (no solvent) at 80℃; for 0.666667h; Friedlaender Quinoline Synthesis; Green chemistry;98%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

3-[3-(trifluoromethyl)phenyl][1,8]naphthyridin-2-amine
1082325-94-7

3-[3-(trifluoromethyl)phenyl][1,8]naphthyridin-2-amine

Conditions
ConditionsYield
With potassium hydroxide for 0.0416667h; Microwave irradiation;98%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

1-(6-methoxypyridin-2-yl)ethan-1-one
21190-93-2

1-(6-methoxypyridin-2-yl)ethan-1-one

2-(6-methoxypyridin-2-yl)-1,8-naphthyridine

2-(6-methoxypyridin-2-yl)-1,8-naphthyridine

Conditions
ConditionsYield
With potassium hydroxide In ethanol at 60℃; for 4h; Inert atmosphere; Schlenk technique;98%

7521-41-7Relevant articles and documents

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Majewicz,Caluwe

, p. 720 (1974)

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Highly efficient synthesis of 2-amino-3-pyridinecarboxaldehyde

Rivera,Hsiao,Cowen,McWilliams,Armstrong,Yasuda,Hughes

, p. 1573 - 1579 (2001)

2-Amino-3-pyridinecarboxaldehyde is synthesized in a highly efficient process via ortho-lithiation of 2-(pivaloyl-amino)pyridine and reaction with DMF, followed by acid hydrolysis. Major impurities were identified and were cleanly eliminated through careful choice of base and solvent.

A dual-model and on-off fluorescent Al3+/Cu2+- chemosensor and the detection of F-/Al3+ with 'in situ' prepared Al3+/Cu2+ complexes

Li, Xiaoya,Yu, Mingming,Yang, Faliu,Liu, Xingjiang,Wei, Liuhe,Li, Zhanxian

, p. 2257 - 2260 (2013)

A multifunctional fluorescent chemosensor for Al3+ and Cu 2+ has been developed, which displays a dual-model and on-off fluorescence response upon addition of Al3+ and Cu2+ respectively. The fluorescence signals of the chemosensor can be restored with F- and ethylenediaminetetraacetic acid (EDTA) disodium for Al 3+ and Cu2+, showing that the binding of the chemosensor and Al3+/Cu2+ is chemically reversible. The 'in situ' prepared Al3+ complex (1·Al) showed high selectivity toward F-, which can be applied to distinguish F- from Cl -, Br- and I-. Moreover, the fluorescence emission intensity of the 'in situ' prepared Cu2+ complex (1·Cu) is increased with the addition of Al3+, demonstrating that 1·Cu could be a good off-on Al3+ sensor candidate.

Diruthenium complexes with a 1,8-Naphthyridine-based Bis(silyl) supporting ligand: Synthesis and structures of complexes containing RuII2(μ-H)2 and RuI2 cores

Kusuma, Indra,Komuro, Takashi,Tobita, Hiromi

, p. 400 - 403 (2018/03/27)

We designed a novel naphthyridine-based supporting ligand involving two silyl coordinating moieties at 2,7-positions, t-BuNBSi, for the synthesis of dinuclear metal complexes. Reaction of a ligand precursor t-BuNBSi(H)2 (1) with Ru3(CO)12 gave a di-μ-hydridodiruthenium(II,II) complex (t-BuNBSi)Ru2(μ-H)2(CO)4 (2). Photoirradiation to 2 resulted in the formation of a diruthenium(I,I) complex (t-BuNBSi)Ru2(CO)6 (3). The SiRuRuSi linkage of 2 takes a zigzag arrangement, whereas that of 3 adopts a roughly linear one.

A formaldehyde fast detection reagent and its preparation method and application

-

Paragraph 0033; 0035; 0038; 0039, (2017/07/04)

The invention discloses a formaldehyde quick detection reagent, a preparation method and an application thereof. A chemical name of the formaldehyde quick detection reagent is 2-amino-3-(3-amino-1H-benzo[d]imidazole)-pyridine of which a chemical structure formula is represented as the formula I. The preparation method comprises following steps: (1) carrying out a reaction to a mixture consisting of nicotinamide and ammonium sulfamate in oil bath at 200 DEG C for 6 hours to obtain an intermediate 3; (2) performing temperature-increasing reflux to the intermediate 3 in an acid environment for 4 hours, cooling the intermediate 3 to room temperature and adjusting the pH value to 7-8 to obtain an intermediate 2; and (3) carrying out a reaction to the intermediate 2 with 1,2,4-triaminobenzene to obtain a target product. The reagent prepared according to the method hereinbefore can quite easily detect the concentration of formaldehyde. The formaldehyde quick detection reagent is simple in synthetic route, is low in cost, is convenient to use, is suitable for actual production application, is high in probe responding speed and is high in sensitivity. The reagent can achieve quick detection quantitatively and high-sensitively of the formaldehyde in environment and foods.

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