1-(P-FLUOROPHENYL)-1,2-DIBROMOETHANE

Base Information

• Chemical Name: 1-(P-FLUOROPHENYL)-1,2-DIBROMOETHANE
• CAS No.: 350-35-6
• Molecular Formula: C8H7 Br2 F
• Molecular Weight: 281.95
• Hs Code.: 2903999090
• Mol file: 350-35-6.mol

Synonyms:1-(a,b-Dibromoethyl)-4-fluorobenzene

Chemical Property of 1-(P-FLUOROPHENYL)-1,2-DIBROMOETHANE

Chemical Property:

• Vapor Pressure: 0.0297mmHg at 25°C
• Refractive Index: 1.582
• Boiling Point: 253.1°Cat760mmHg
• Flash Point: 106.9°C
• PSA: 0.00000
• Density: 1.835g/cm³
• LogP: 3.65660
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

1-(1,2-Dibromoethyl)-4-fluorobenzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(P-FLUOROPHENYL)-1,2-DIBROMOETHANE

There total 6 articles about 1-(P-FLUOROPHENYL)-1,2-DIBROMOETHANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

para-fluorostyrene (405-99-2) → 1-(1,2-dibromoethyl)-4-fluorobenzene (350-35-6)

Guidance literature:

With bromine; In chloroform; at 0 ℃; Inert atmosphere;

DOI:10.1055/s-0036-1589143

Reference yield:

(2-bromoethyl)-4-fluorobenzene (332-42-3) → 1-(1,2-dibromoethyl)-4-fluorobenzene (350-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / 200 - 220 °C

2: bromine

With potassium hydroxide; bromine;

DOI:10.1021/ja01209a038

Reference yield:

→ 1-(1,2-dibromoethyl)-4-fluorobenzene (350-35-6) + 1-(2-bromo-1-methoxyethyl)-4-fluorobenzene + 3-Bromo-3-(4-fluoro-phenyl)-propionic acid methyl ester + methyl 3-(4-fluorophenyl)-3-methoxypropanoate

Guidance literature:

With carbon monoxide; bromine; In methanol; dichloromethane; Further byproducts given; 1.) 0 deg C, 0.5 h, 2.) 40 deg C, 0.5 h;

DOI:10.1016/S0022-328X(00)85703-4

upstream raw materials:

para-fluorostyrene

methanol

carbon monoxide

(2-bromoethyl)-4-fluorobenzene

Downstream raw materials:

4-(p-fluorophenyl)-3-cyclohexen-1-ol

3-(4-fluorobenzene)-2H-azirine

para-fluorostyrene

2-bromo-4'-fluoroacetophenone

Refernces

• 1、 Mulina, Olga M.,Ilovaisky, Alexey I.,Opatz, Till,Terent'ev, Alexander O.. "Photoredox-catalyzed synthesis of N-unsubstituted enaminosulfones from vinyl azides and sulfinates". supporting information. . Retrieved 2021/01/11.
• 2、 Paveliev, Stanislav A.,Churakov, Artem I.,Alimkhanova, Liliya S.,Segida, Oleg O.,Nikishin, Gennady I.,Terent'ev, Alexander O.. "Electrochemical Synthesis of O-Phthalimide Oximes from α-Azido Styrenes via Radical Sequence: Generation, Addition and Recombination of Imide-N-Oxyl and Iminyl Radicals with C?O/N?O Bonds Formation". supporting information. p. 3864 - 3871. Retrieved 2020/07/30.