4-Naphthalen-1-yl-morpholine

Base Information

• Chemical Name: 4-Naphthalen-1-yl-morpholine
• CAS No.: 98223-72-4
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.279
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID20375045
• Nikkaji Number: J923.226E
• Wikidata: Q82163588
• Mol file: 98223-72-4.mol

Synonyms:4-Naphthalen-1-yl-morpholine;98223-72-4;4-naphthalen-1-ylmorpholine;4-(Naphthalen-1-yl)morpholine;morpholinonaphthalen;4-(1-Naphthyl)morpholine;SCHEMBL2320577;DTXSID20375045;MFCD03425051;AKOS015966144

Chemical Property of 4-Naphthalen-1-yl-morpholine

Chemical Property:

• Melting Point: 83 °C
• Boiling Point: 380.5±35.0 °C(Predicted)
• PKA: 4.32±0.40(Predicted)
• PSA: 12.47000
• Density: 1.141±0.06 g/cm3(Predicted)
• LogP: 2.74140
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 213.115364102
• Heavy Atom Count: 16
• Complexity: 225

Purity/Quality:

98% ^*data from raw suppliers

4-(Naphthalen-1-yl)morpholine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=CC=CC3=CC=CC=C32

Technology Process of 4-Naphthalen-1-yl-morpholine

There total 27 articles about 4-Naphthalen-1-yl-morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + 1-Bromonaphthalene (90-11-9) → N-(1-naphthyl)morpholine (98223-72-4)

Guidance literature:

With (1,3-bis(2,6-diisopropylphenyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene)Pd(cinnamyl, 3-phenylallyl)Cl; sodium t-butanolate; In neat (no solvent); at 110 ℃; for 12h; Inert atmosphere; Green chemistry;

DOI:10.1002/ejoc.201501616

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + 2-(naphthalen-1-yloxy)pyridine (509073-87-4) → N-(1-naphthyl)morpholine (98223-72-4)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; lithium tert-butoxide; 1,3-bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene monohydrochloride; In 1,4-dioxane; at 100 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.7b01549

Reference yield: 98.0%

morpholine (110-91-8,99108-56-2) + 1-Chloronaphthalene (90-13-1) → N-(1-naphthyl)morpholine (98223-72-4)

Guidance literature:

With Pd-PEPPSI-IPr^An; potassium tert-butylate; In 1,4-dioxane; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c1cc15503b

upstream raw materials:

morpholine

1-Cyanonaphthalene

1-Bromonaphthalene

4-(benzoyloxy)morpholine

Downstream raw materials:

5,5-dimethyl-2-(naphthalen-1-yl)-1,3,2-dioxaborinane

C₃₁H₃₅N₃O

Refernces

• 1、 Akiyama, Toshiki,Arai, Masayoshi,Arisawa, Mitsuhiro,Haneoka, Hitoshi,Harada, Kazuo,Murai, Kenichi,Murakami, Yosuke,Ohki, Yuuta,Ohta, Ryousuke,Sako, Makoto,Sirimangkalakitti, Natchanun,Suzuki, Takeyuki,Takahashi, Naoyuki,Takehara, Tsunayoshi,Yamada, Makito. "Product selective reaction controlled by the combination of palladium nanoparticles, continuous microwave irradiation, and a co-existing solid; ligand-free Buchwald-Hartwig aminationvs.aryne amination". supporting information. p. 8131 - 8137. Retrieved 2021/10/29.
• 2、 -. "Preparation method of pyrazole bistriazolylphosphine compound". Paragraph 0231-0234. . Retrieved 2020/05/30.