Xn:Harmful;90-13-1Relevant articles and documents
Frater,Havinga
, p. 4603 (1969)
Method for preparing 1 - chloronaphthalene
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Paragraph 0013-0022, (2021/03/23)
The invention specifically relates to a novel preparation method for 1-chloronaphthalene, belonging to the technical field of fine chemical engineering. The preparation method comprises a step of reacting naphthalene with chlorine at 50 to 80 DEG C and at a normal pressure so as to obtain a reaction solution in the presence of a solvent and a catalyst, wherein the solvent is kerosene; the catalystis one or more selected from a group consisting of ferric sulfide, ferrous sulfide and copper sulfide; reaction temperature is 50 to 80 DEG C; and reaction time is 2 to 3 h. According to the preparation method for 1-chloronaphthalene, the conversion rate of naphthalene is 100%, the content of 1-chloronaphthalene in the reaction solution is 90% or more, and the reaction is carried out at normal temperature and normal pressure; so energy consumption is lowered, and the conversion rate is increased.
Nickel-catalyzed cross-coupling reaction of carbamates with silylmagnesium reagents
Murugesan, Vetrivelan,Balakrishnan, Venkadesh,Rasappan, Ramesh
, p. 293 - 298 (2019/08/12)
The C–O bonds are kinetically inert in cross-coupling reactions compared to those of carbon–halogen bonds. Thus, developing methodologies for the activation of C–O bonds in cross-coupling reactions remains a major challenge. We disclose an unprecedented nickel mediated cross-coupling of carbamates with silylmagnesium reagents that does not require the expensive silylboranes. Silylmagnesium reagents were prepared from either silyllithium or silyl iodides. This methodology is distinguished by the synthesis of trimethylsilyl coupled product and its synthetic applications. Kinetic studies and radical clock experiments revealed the rate-limiting C–O bond cleavage, half order with respect to the catalyst and a non-radical transition state.
