leukotriene A5 methyl ester

Base Information

• Chemical Name: leukotriene A5 methyl ester
• CAS No.: 90121-06-5
• Molecular Formula: C₂₁H₃₀O₃
• Molecular Weight: 330.467
• Mol file: 90121-06-5.mol

Synonyms:leukotriene A5 methyl ester

Chemical Property of leukotriene A5 methyl ester

Chemical Property:

• PSA: 38.83000
• LogP: 5.06830
• Storage Temp.: ?20°C

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s): F,Xn
• Hazard Codes: F,Xn
• Statements: 11-20/21/22-36/37/38-40
• Safety Statements: 9-16-26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of leukotriene A5 methyl ester

There total 6 articles about leukotriene A5 methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

((3Z,6Z)-Nona-3,6-dienylidene)-triphenyl-λ5-phosphane (90121-05-4) + 4-[3-((1E,3E)-5-Oxo-penta-1,3-dienyl)-oxiranyl]-butyric acid methyl ester → 4-[((1E,3E,5Z,8Z,11Z)-3-Tetradeca-1,3,5,8,11-pentaenyl)-oxiranyl]-butyric acid methyl ester (90121-06-5)

Guidance literature:

at -78 ℃; for 0.0833333h;

DOI:10.1002/ardp.19843170317

Reference yield:

1-bromo-pent-2-yne (16400-32-1) → 4-[((1E,3E,5Z,8Z,11Z)-3-Tetradeca-1,3,5,8,11-pentaenyl)-oxiranyl]-butyric acid methyl ester (90121-06-5)

Guidance literature:

Multi-step reaction with 6 steps

1: DBU, CuI, HMPT / tetrahydrofuran

2: H₂, (C₂H₅)N / Lindlar catalyst / tetrahydrofuran

3: CBr₄, P(C₆H₅)3 / CH₂Cl₂ / 0.17 h / 0 °C

4: acetonitrile / Heating

5: BuLi, HMPT / tetrahydrofuran / -78 °C

6: 30 percent / 0.08 h / -78 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; n-butyllithium; carbon tetrabromide; (C₂H₅)N; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; Lindlar's catalyst; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1002/ardp.19843170317

Reference yield:

nona-3,6-diyn-1-ol (57386-91-1) → 4-[((1E,3E,5Z,8Z,11Z)-3-Tetradeca-1,3,5,8,11-pentaenyl)-oxiranyl]-butyric acid methyl ester (90121-06-5)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂, (C₂H₅)N / Lindlar catalyst / tetrahydrofuran

2: CBr₄, P(C₆H₅)3 / CH₂Cl₂ / 0.17 h / 0 °C

3: acetonitrile / Heating

4: BuLi, HMPT / tetrahydrofuran / -78 °C

5: 30 percent / 0.08 h / -78 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; carbon tetrabromide; (C₂H₅)N; hydrogen; triphenylphosphine; Lindlar's catalyst; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1002/ardp.19843170317

upstream raw materials:

((3Z,6Z)-Nona-3,6-dienylidene)-triphenyl-λ⁵-phosphane

1-bromo-pent-2-yne

nona-3,6-diyn-1-ol

(Z,Z)-1-hydroxynona-3,6-diene

Downstream raw materials:

LTE5

LTD5

LTC5

Refernces