Methyl (2S,5R)-1-cbz-5-hydroxy-6-methoxypipecolinate

Base Information Edit

Chemical Name:Methyl (2S,5R)-1-cbz-5-hydroxy-6-methoxypipecolinate
CAS No.:824943-45-5
Molecular Formula:C16H21 N O6
Molecular Weight:323.346
Hs Code.:
DSSTox Substance ID:DTXSID00472283
Nikkaji Number:J2.141.943E
Mol file:824943-45-5.mol

Synonyms:824943-45-5;METHYL (2S,5R)-1-CBZ-5-HYDROXY-6-METHOXYPIPECOLINATE;METHYL(2S,5R)-1-CBZ-5-HYDROXY-6-METHOXYPIPECOLINATE;DTXSID00472283;(2S,5R)-1-Benzyl 2-methyl 5-hydroxy-6-methoxypiperidine-1,2-dicarboxylate

Suppliers and Price of Methyl (2S,5R)-1-cbz-5-hydroxy-6-methoxypipecolinate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
METHYL(2S,5R)-1-CBZ-5-HYDROXY-6-METHOXYPIPECOLINATE 95.00%
100G
$ 2758.14

Total 2 raw suppliers

Chemical Property of Methyl (2S,5R)-1-cbz-5-hydroxy-6-methoxypipecolinate Edit

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.559
Boiling Point:456.991°C at 760 mmHg
Flash Point:230.18°C
PSA：85.30000
Density:1.276g/cm³
LogP:1.23190
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:323.13688739
Heavy Atom Count:23
Complexity:409

Purity/Quality:

99% ^*data from raw suppliers

METHYL(2S,5R)-1-CBZ-5-HYDROXY-6-METHOXYPIPECOLINATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1C(CCC(N1C(=O)OCC2=CC=CC=C2)C(=O)OC)O
Isomeric SMILES:COC1[C@@H](CC[C@H](N1C(=O)OCC2=CC=CC=C2)C(=O)OC)O

Technology Process of Methyl (2S,5R)-1-cbz-5-hydroxy-6-methoxypipecolinate

There total 12 articles about Methyl (2S,5R)-1-cbz-5-hydroxy-6-methoxypipecolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 824943-43-3
(S)-2-benzyloxycarbonylamino-5-(2-[1,3]dioxolanyl)-pentanoic acid methyl ester

: 824943-45-5
(2S,5R)-5-hydroxy-6-methoxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / TsOH*H₂ODMF / toluene / 2 h / 115 °C

2: 90 percent / Oxone(R); NaHCO₃ / 20 °C

With oxone; sodium hydrogencarbonate; toluene-4-sulfonic acid; In toluene;
DOI:10.1021/ol047774v

Reference yield:

: 852822-01-6
(S)-2-Benzyloxycarbonylamino-5-[1,3]dioxolan-2-yl-pentanoic acid

: 824943-45-5
(2S,5R)-5-hydroxy-6-methoxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / K₂CO₃ / dimethylformamide / 2 h / 20 °C

2: 98 percent / TsOH*H₂ODMF / toluene / 2 h / 115 °C

3: 90 percent / Oxone(R); NaHCO₃ / 20 °C

With oxone; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol047774v

Reference yield:

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 824943-45-5
(2S,5R)-5-hydroxy-6-methoxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / aq. NaOH; aq.NaHCO₃ / dioxane

2: 97 percent / K₂CO₃ / dimethylformamide / 2 h / 20 °C

3: 98 percent / TsOH*H₂ODMF / toluene / 2 h / 115 °C

4: 90 percent / Oxone(R); NaHCO₃ / 20 °C

With sodium hydroxide; oxone; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol047774v