(2S,5R)-5-HYDROXYPIPECOLIC ACID HCL

Base Information

• Chemical Name: (2S,5R)-5-HYDROXYPIPECOLIC ACID HCL
• CAS No.: 824943-40-0
• Molecular Formula: C6H11NO3^.HCl
• Molecular Weight: 181.619
• Hs Code.: 2933399990
• Mol file: 824943-40-0.mol

Synonyms:2-Piperidinecarboxylicacid, 5-hydroxy-, hydrochloride, (2S,5R)- (9CI);(2S,5R)-5-Hydroxypipecolicacid hydrochloride;

Chemical Property of (2S,5R)-5-HYDROXYPIPECOLIC ACID HCL

Chemical Property:

• Boiling Point: 374.2 °C at 760 mmHg
• Flash Point: 180.1 °C
• PSA: 69.56000
• LogP: 0.31470

Purity/Quality:

98% ^*data from raw suppliers

(2S,5R)-5-HydroxypipecolicAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S,5R)-5-HYDROXYPIPECOLIC ACID HCL

There total 7 articles about (2S,5R)-5-HYDROXYPIPECOLIC ACID HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-3,4-dihydro-2H-pyridine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (227758-97-6) → (2S,5R)-5-hydroxy-piperidine-2-carboxylic acid hydrochloride (824943-40-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / Oxone(R); NaHCO₃ / 20 °C

2: H₂ / Pd/C / methanol / 1.5 h

3: 57 mg / aq. HCl / 2.5 h / Heating

With hydrogenchloride; oxone; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol;

DOI:10.1021/ol047774v

Reference yield:

(2S,5R)-5-hydroxy-6-methoxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (824943-45-5) → (2S,5R)-5-hydroxy-piperidine-2-carboxylic acid hydrochloride (824943-40-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol / 1.5 h

2: 57 mg / aq. HCl / 2.5 h / Heating

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/ol047774v

Reference yield:

(S)-2-benzyloxycarbonylamino-5-(2-[1,3]dioxolanyl)-pentanoic acid methyl ester (824943-43-3) → (2S,5R)-5-hydroxy-piperidine-2-carboxylic acid hydrochloride (824943-40-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / TsOH*H₂ODMF / toluene / 2 h / 115 °C

2: 90 percent / Oxone(R); NaHCO₃ / 20 °C

3: H₂ / Pd/C / methanol / 1.5 h

4: 57 mg / aq. HCl / 2.5 h / Heating

With hydrogenchloride; oxone; hydrogen; sodium hydrogencarbonate; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; toluene;

DOI:10.1021/ol047774v

upstream raw materials:

(2S,5R)-methyl 5-hydroxypiperidine-2-carboxylate

(2S)-3,4-dihydro-2H-pyridine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

(2S,5R)-5-hydroxy-6-methoxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

(S)-2-benzyloxycarbonylamino-5-(2-[1,3]dioxolanyl)-pentanoic acid methyl ester

Refernces