Technology Process of (Z)-1-benzyl-5-benzylidene-4-methyl-1,5-dihydro-2H-pyrrol-2-one
There total 2 articles about (Z)-1-benzyl-5-benzylidene-4-methyl-1,5-dihydro-2H-pyrrol-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C19H19NO;
With
Iodine monochloride;
In
dichloromethane;
at 25 ℃;
for 3h;
Darkness;
Inert atmosphere;
With
water; sodium thiosulfate;
In
dichloromethane;
regioselective reaction;
DOI:10.1055/s-0028-1083257
- Guidance literature:
-
(Z)-3-iodobut-2-enoic acid;
With
potassium carbonate;
In
isopropyl alcohol;
at -78 ℃;
Inert atmosphere;
Schlenk technique;
phenylacetylene; benzylamine;
With
copper(l) iodide;
In
isopropyl alcohol;
at 50 ℃;
Inert atmosphere;
Sealed tube;
Schlenk technique;
With
hydrogenchloride;
In
isopropyl alcohol;
at 0 - 50 ℃;
Overall yield = 76 percent;
DOI:10.1021/acs.oprd.9b00438