3-Pyrrolidinol, 1-(3-fluorophenyl)-, 3-(4-methylbenzenesulfonate), (3R)-

Base Information

• Chemical Name: 3-Pyrrolidinol, 1-(3-fluorophenyl)-, 3-(4-methylbenzenesulfonate), (3R)-
• CAS No.: 873945-29-0
• Molecular Formula: C17H18 F N O3 S
• Molecular Weight: 335.39
• Hs Code.: 2933990090
• Mol file: 873945-29-0.mol

Synonyms:3-Pyrrolidinol,1-(3-fluorophenyl)-, 4-methylbenzenesulfonate (ester), (3R)- (9CI)

Chemical Property of 3-Pyrrolidinol, 1-(3-fluorophenyl)-, 3-(4-methylbenzenesulfonate), (3R)-

Chemical Property:

• Melting Point: 268-269?C (dec.)
• PSA: 54.99000
• Density: 1.34
• LogP: 4.26410
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(R)-1-(3-Fluorophenyl)pyrrolidin-3-yl 4-methylbenzenesulfonate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R52/53 :
• Hazard Codes: R52/53 :
• Statements: 52/53
• Safety Statements: 61

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Labelled fluorinated quinolone antibacterial.

Technology Process of 3-Pyrrolidinol, 1-(3-fluorophenyl)-, 3-(4-methylbenzenesulfonate), (3R)-

There total 1 articles about 3-Pyrrolidinol, 1-(3-fluorophenyl)-, 3-(4-methylbenzenesulfonate), (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-1-(3-fluorophenyl)pyrrolidin-3-ol (850834-38-7) + p-toluenesulfonyl chloride (98-59-9) → (R)-1-(3-fluorophenyl)pyrrolidin-3-yl p-toluene-4-sulphonate (873945-29-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

(R)-1-(3-fluorophenyl)pyrrolidin-3-yl p-toluene-4-sulphonate (873945-29-0) + benzyl 3-hydroxy-4-(4-hydroxyphenyl)-5-triisopropylsilanyloxypiperidine-1-carboxylate (911210-38-3) → benzyl 4-{4-[(S)-1-(3-fluorophenyl)pyrrolidin-3-yloxy]phenyl}-3-hydroxy-5-triisopropylsilanyloxypiperidine-1-carboxylate

Guidance literature:

With caesium carbonate; In acetonitrile; at 80 ℃; for 2h;

upstream raw materials:

(R)-1-(3-fluorophenyl)pyrrolidin-3-ol

p-toluenesulfonyl chloride

Refernces