benzyl 4-amino-3-({4-[bis(tert-butoxycarbonyl)amino]-2-methylbutan-2-yl}amino)benzoate

Base Information

• Chemical Name: benzyl 4-amino-3-({4-[bis(tert-butoxycarbonyl)amino]-2-methylbutan-2-yl}amino)benzoate
• CAS No.: 1311569-04-6
• Molecular Formula: C₂₉H₄₁N₃O₆
• Molecular Weight: 527.661
• Mol file: 1311569-04-6.mol

Synonyms:benzyl 4-amino-3-({4-[bis(tert-butoxycarbonyl)amino]-2-methylbutan-2-yl}amino)benzoate

Chemical Property of benzyl 4-amino-3-({4-[bis(tert-butoxycarbonyl)amino]-2-methylbutan-2-yl}amino)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 4-amino-3-({4-[bis(tert-butoxycarbonyl)amino]-2-methylbutan-2-yl}amino)benzoate

There total 5 articles about benzyl 4-amino-3-({4-[bis(tert-butoxycarbonyl)amino]-2-methylbutan-2-yl}amino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

benzyl 3-({4-[bis(tert-butoxycarbonyl)amino]-2-methylbutan-2-yl}amino)-4-nitrobenzoate (1311569-03-5) → benzyl 4-amino-3-({4-[bis(tert-butoxycarbonyl)amino]-2-methylbutan-2-yl}amino)benzoate (1311569-04-6)

Guidance literature:

With acetic acid; zinc; In methanol; for 0.333333h;

Reference yield:

3-fluoro-4-nitrobenzoyl chloride (157665-51-5) → benzyl 4-amino-3-({4-[bis(tert-butoxycarbonyl)amino]-2-methylbutan-2-yl}amino)benzoate (1311569-04-6)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 16 h

2: potassium carbonate / acetonitrile / 16 h / 80 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C

4: zinc; acetic acid / methanol / 0.33 h

With pyridine; di-isopropyl azodicarboxylate; potassium carbonate; acetic acid; triphenylphosphine; zinc; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

3-fluoro-4-nitrobenzoic acid (403-21-4) → benzyl 4-amino-3-({4-[bis(tert-butoxycarbonyl)amino]-2-methylbutan-2-yl}amino)benzoate (1311569-04-6)

Guidance literature:

Multi-step reaction with 5 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

2: pyridine / dichloromethane / 16 h

3: potassium carbonate / acetonitrile / 16 h / 80 °C

4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C

5: zinc; acetic acid / methanol / 0.33 h

With pyridine; oxalyl dichloride; di-isopropyl azodicarboxylate; potassium carbonate; acetic acid; triphenylphosphine; zinc; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

3-fluoro-4-nitrobenzoyl chloride

benzyl 3-fluoro-4-nitrobenzoate

3-fluoro-4-nitrobenzoic acid

benzyl 3-[(4-hydroxy-2-methylbutan-2-yl)amino]-4-nitrobenzoate

Downstream raw materials:

C₃₂H₄₁N₃O₈

benzyl 5,5-dimethyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]benzimidazole-8-carboxylate

Refernces