4'-(tert-butyldimethylsilyloxy)-3,5-dimethoxybenzhydrol

Base Information

• Chemical Name: 4'-(tert-butyldimethylsilyloxy)-3,5-dimethoxybenzhydrol
• CAS No.: 441351-41-3
• Molecular Formula: C₂₁H₃₀O₄Si
• Molecular Weight: 374.552
• Mol file: 441351-41-3.mol

Synonyms:4'-(tert-butyldimethylsilyloxy)-3,5-dimethoxybenzhydrol

Chemical Property of 4'-(tert-butyldimethylsilyloxy)-3,5-dimethoxybenzhydrol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-(tert-butyldimethylsilyloxy)-3,5-dimethoxybenzhydrol

There total 2 articles about 4'-(tert-butyldimethylsilyloxy)-3,5-dimethoxybenzhydrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

t-butyldimethylsilyl-4-bromophenol (67963-68-2) + 3,5-dimethoxybenzaldehdye (7311-34-4) → 4'-(tert-butyldimethylsilyloxy)-3,5-dimethoxybenzhydrol (441351-41-3)

Guidance literature:

t-butyldimethylsilyl-4-bromophenol; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.25h;

3,5-dimethoxybenzaldehdye; In tetrahydrofuran; for 6h; Further stages.;

DOI:10.1021/jm010119y

Reference yield:

4-bromo-phenol (106-41-2) → 4'-(tert-butyldimethylsilyloxy)-3,5-dimethoxybenzhydrol (441351-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 87 percent / imidazole / CH₂Cl₂ / 12 h

2.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C

2.2: 83 percent / tetrahydrofuran / 6 h

With 1H-imidazole; n-butyllithium; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm010119y

Reference yield: 80.0%

4'-(tert-butyldimethylsilyloxy)-3,5-dimethoxybenzhydrol (441351-41-3) → 4'-(tert-butyldimethylsilyloxy)-3,5-dimethoxybenzophenone (441351-43-5)

Guidance literature:

With dipyridinium dichromate; 4 A molecular sieve; In dichloromethane; for 24h;

DOI:10.1021/jm010119y

upstream raw materials:

t-butyldimethylsilyl-4-bromophenol

3,5-dimethoxybenzaldehdye

4-bromo-phenol

Downstream raw materials:

4'-(tert-butyldimethylsilyloxy)-3,5-dimethoxybenzophenone

Refernces