4-Fluoropiperidine

Base Information

• Chemical Name: 4-Fluoropiperidine
• CAS No.: 78197-27-0
• Molecular Formula: C5H10FN
• Molecular Weight: 103.14
• Hs Code.: 2933399090
• European Community (EC) Number: 851-922-2
• DSSTox Substance ID: DTXSID30999438
• Wikidata: Q72476586
• ChEMBL ID: CHEMBL1162291
• Mol file: 78197-27-0.mol

Synonyms:4-fluoropiperidine;78197-27-0;Piperidine, 4-fluoro-;4-fluoro-piperidine;MFCD03093851;4-fluoropiperdine;4-Fluoropyperidine;4-Fluoro-piperidinium;SCHEMBL9503;CHEMBL1162291;DTXSID30999438;QBLLOOKBLTTXHB-UHFFFAOYSA-N;BBL102081;STL555880;AKOS005064106;AB13264;BS-24472;SY020129;CS-0101735;FT-0692487;EN300-41396;I11481;A852875

Chemical Property of 4-Fluoropiperidine

Chemical Property:

• Vapor Pressure: 15.428mmHg at 25°C
• Refractive Index: 1.421
• Boiling Point: 120.2±33.0℃ (760 Torr)
• PKA: 9.33±0.10(Predicted)
• Flash Point: 26.5±25.4℃
• PSA: 12.03000
• Density: 0.97±0.1 g/cm3 (20 ºC 760 Torr)
• LogP: 1.03670
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 103.079727485
• Heavy Atom Count: 7
• Complexity: 50

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoropiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1F

Technology Process of 4-Fluoropiperidine

There total 7 articles about 4-Fluoropiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 4-fluoropiperidine-1-carboxylate (690257-75-1) → 4-fluoropiperidine (78197-27-0)

Guidance literature:

With hydrogen; palladium(II) hydroxide/carbon; In ethanol; for 12h; under 2068.65 Torr;

Reference yield:

4-fluoropiperidine hydrochloride (57395-89-8) → 4-fluoropiperidine (78197-27-0)

Guidance literature:

With sodium hydroxide; In tert-Amyl alcohol; water;

DOI:10.1021/op700183q

Reference yield:

tert-butyl 4-fluoropiperidine-1-carboxylate (178181-55-0) → 4-fluoropiperidine (78197-27-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 3h;

DOI:10.1021/jm031122f

upstream raw materials:

tert-butyl 4-fluoropiperidine-1-carboxylate

t-butyl 4-hydroxy piperidine-1-carboxylate

benzyl 4-fluoropiperidine-1-carboxylate

4-fluoropiperidine hydrochloride

Downstream raw materials:

4-fluoropiperidine hydrochloride

4-[(4-fluoropiperidin-1-yl)carbonyl]benzenesulfonamide

C₁₈H₂₂FN₃O₄S

C₂₉H₄₂FN₃O₂

Refernces

• 1、 Deng, Xiaohu,Liang, Jimmy T.,Liu, Jing,McAllister, Heather,Schubert, Garsten,Mani, Neelakandha S.. "A practical synthesis of enantiopure 7-alkoxy-4-aryl- tetrahydroisoquinoline, a dual serotonin reuptake inhibitor/histamine H 3 antagonist". . p. 1043 - 1050. Retrieved 2012/12/30.
• 2、 -. "CYCLOHEXYLALANINE DERIVATIVES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES". Page/Page column 52. . Retrieved 2010/02/15.