tert-butyl 4-fluoropiperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-fluoropiperidine-1-carboxylate
• CAS No.: 178181-55-0
• Molecular Formula: C10H18FNO2
• Molecular Weight: 203.257
• Hs Code.: 2933399090
• Mol file: 178181-55-0.mol

Synonyms:tert-butyl 4-fluoropiperidine-1-carboxylate;4-Fluoropiperidine-N-carboxylic acid tert-butyl ester

Chemical Property of tert-butyl 4-fluoropiperidine-1-carboxylate

Chemical Property:

• PSA: 29.54000
• LogP: 2.29330

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-N-Boc-4-fluoropiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-fluoropiperidine-1-carboxylate

There total 4 articles about tert-butyl 4-fluoropiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-fluoropiperidine (78197-27-0) + carbon monoxide (201230-82-2) + tert-butyl alcohol (75-65-0) → tert-butyl 4-fluoropiperidine-1-carboxylate (178181-55-0)

Guidance literature:

With gold(III) chloride; copper(l) iodide; at 20 ℃; for 24h; under 750.075 - 3000.3 Torr;

DOI:10.1002/cssc.202102400

Reference yield: 89.0%

2-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)-2-oxoacetic acid → tert-butyl 4-fluoropiperidine-1-carboxylate (178181-55-0)

Guidance literature:

With dipotassium hydrogenphosphate; Ir[dF(CF₃)ppy]2(dtbbpy)PF₆; Selectfluor; In water; acetone; at 30 ℃; for 4h; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1016/j.tet.2019.05.043

Reference yield: 44.0%

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → tert-butyl 4-fluoropiperidine-1-carboxylate (178181-55-0)

Guidance literature:

With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at -78 - 20 ℃; for 3h;

upstream raw materials:

t-butyl 4-hydroxy piperidine-1-carboxylate

4-fluoropiperidine

carbon monoxide

tert-butyl alcohol

Downstream raw materials:

5-(4-fluorophenyl)-3-(4-(4-fluoropiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

4-(4-fluoropiperidin-1-yl)-N'-hydroxy-3-(trifluoromethyl)benzimidamide

5-[3-(4-fluoro-3-trifluoromethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-2-(4-fluoro-piperidin-1-yl)-benzonitrile

5-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-2-(4-fluoro-piperidin-1-yl)-benzonitrile

Refernces

• 1、 González-Esguevillas, María,Miró, Javier,Jeffrey, Jenna L.,MacMillan, David W.C.. "Photoredox-catalyzed deoxyfluorination of activated alcohols with Selectfluor". . p. 4222 - 4227. Retrieved 2019/06/13.
• 2、 -. "PYRAZOLE DERIVATIVES". Page/Page column 34. . Retrieved 2010/11/26.