6-Bromo-1-methyl-1H-indazole

Base Information

• Chemical Name: 6-Bromo-1-methyl-1H-indazole
• CAS No.: 590417-94-0
• Molecular Formula: C8H7BrN2
• Molecular Weight: 211.061
• Hs Code.: 2933990090
• Mol file: 590417-94-0.mol

Synonyms:6-Bromo-1-methylindazole;1H-indazole, 6-bromo-1-methyl-;

Chemical Property of 6-Bromo-1-methyl-1H-indazole

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.663
• Boiling Point: 293.616 °C at 760 mmHg
• PKA: 0.66±0.30(Predicted)
• Flash Point: 131.374 °C
• PSA: 17.82000
• Density: 1.607 g/cm³
• LogP: 2.33580
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-1-methyl-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromo-1-methyl-1H-indazole

There total 2 articles about 6-Bromo-1-methyl-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

6-bromo-1H-indazole (79762-54-2) + methyl iodide (74-88-4) → 6-bromo-1-methyl-1H-indazole (590417-94-0)

Guidance literature:

6-bromo-1H-indazole; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 2h;

methyl iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 3h;

Reference yield:

6-bromo-1H-indazole (79762-54-2) + methyl iodide (74-88-4) → 6-bromo-1-methyl-1H-indazole (590417-94-0) + 6-bromo-2-methyl-2H-indazole (590417-95-1)

Guidance literature:

6-bromo-1H-indazole; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h;

Reference yield: 98.0%

methanol (67-56-1) + 6-bromo-1-methyl-1H-indazole (590417-94-0) + carbon monoxide (201230-82-2) → 1-methyl-1H-indazole-6-carboxylic acid methyl ester (1007219-73-9)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; at 110 ℃; for 20h; under 37503.8 Torr; Pressure; Temperature; Autoclave; Industrial scale;

upstream raw materials:

6-bromo-1H-indazole

methyl iodide

Downstream raw materials:

1-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole

Refernces

• 1、 Zhou, Guangyan,Chu, Shidong,Nemati, Ariana,Huang, Chunsheng,Snyder, Beth A.,Ptak, Roger G.,Gochin, Miriam. "Investigation of the molecular characteristics of bisindole inhibitors as HIV-1 glycoprotein-41 fusion inhibitors". supporting information. p. 533 - 542. Retrieved 2018/11/06.
• 2、 -. "N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS". Paragraph 000807. . Retrieved 2015/05/19.