METHYL ESTER, 4,5-BIS(2-METHOXYETHOXY)-2-NITROBENZOIC ACID

Base Information

• Chemical Name: METHYL ESTER, 4,5-BIS(2-METHOXYETHOXY)-2-NITROBENZOIC ACID
• CAS No.: 501684-22-6
• Molecular Formula: C14H19 N O8
• Molecular Weight: 329.307
• Mol file: 501684-22-6.mol

Synonyms:METHYL ESTER, 4,5-BIS(2-METHOXYETHOXY)-2-NITROBENZOIC ACID

Chemical Property of METHYL ESTER, 4,5-BIS(2-METHOXYETHOXY)-2-NITROBENZOIC ACID

Chemical Property:

• Boiling Point: 456.8±45.0 °C(Predicted)
• PSA: 109.04000
• Density: 1.238±0.06 g/cm3(Predicted)
• LogP: 1.95500

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL ESTER, 4,5-BIS(2-METHOXYETHOXY)-2-NITROBENZOIC ACID

There total 9 articles about METHYL ESTER, 4,5-BIS(2-METHOXYETHOXY)-2-NITROBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

methyl 3,4-bis{[2-(methyloxy)ethyl]oxy}benzoate (179688-14-3) → methyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate (501684-22-6)

Guidance literature:

With sulfuric acid; nitric acid; In chloroform; at 0 - 40 ℃; for 1.5h; Temperature; Concentration;

Reference yield: 95.2%

→ methyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate (501684-22-6)

Guidance literature:

Reference yield:

3,4-Dihydroxybenzoic acid (99-50-3) → methyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate (501684-22-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / H₂SO₄ / Heating

2: 99 percent / K₂CO₃; TBAI / acetone / Heating

3: 85 percent / HNO₃; Ac₂O / 20 °C

With sulfuric acid; nitric acid; acetic anhydride; tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetone;

DOI:10.1016/j.tetlet.2006.02.043

upstream raw materials:

methyl 3,4-bis{[2-(methyloxy)ethyl]oxy}benzoate

3,4-Dihydroxybenzoic acid

3,4-dihydroxybenzoic acid methyl ester

Ethyl protocatechuate

Downstream raw materials:

4,5-bis (2-methoxyethoxy)-2-nitrobenzoic acid

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-[3-(3-dicyclohexylamino-prop-1-ynyl)-phenyl]-amine

Refernces

• 1、 Zheng, Youguang,Sun, Min,Liu, Yi,Li, Mingdong,Ji, Min. "Design, synthesis of novel quinazolone alkaloids derivatives as potential antitumor agents". scheme or table. p. 295 - 300. Retrieved 2012/06/01.
• 2、 Nakamura, Hiroyuki,Onagi, Shinya. "Synthesis and biological evaluation of allenic quinazolines using palladium-catalyzed hydride-transfer reaction". . p. 2539 - 2542. Retrieved 2007/10/03.