Technology Process of 3-chloro-4-[8-ethyl-2-(methylsulfanyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]benzonitrile
There total 8 articles about 3-chloro-4-[8-ethyl-2-(methylsulfanyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]benzonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0);
In
N,N-dimethyl-formamide;
at 70 ℃;
for 12h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / -15 °C
2: sodium tetrahydroborate; water / tetrahydrofuran / 1 h / -5 - 0 °C
3: phosphorus tribromide / 1,2-dichloro-ethane / 0.67 h / 0 - 10 °C
4: tetrabutyl-ammonium chloride / water; 1,2-dichloro-ethane / 4 h / 20 °C
5: sodium hydroxide / 4 h / Reflux
6: thionyl chloride / 1 h / Reflux
7: ISOPROPYLAMIDE; caesium carbonate / 2 h / 100 °C
8: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere
With
4-methyl-morpholine; 1,1'-bis-(diphenylphosphino)ferrocene; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium(0); thionyl chloride; ISOPROPYLAMIDE; tetrabutyl-ammonium chloride; water; phosphorus tribromide; caesium carbonate; sodium hydroxide;
In
tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tetrabutyl-ammonium chloride / water; 1,2-dichloro-ethane / 4 h / 20 °C
2: sodium hydroxide / 4 h / Reflux
3: thionyl chloride / 1 h / Reflux
4: ISOPROPYLAMIDE; caesium carbonate / 2 h / 100 °C
5: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere
With
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); thionyl chloride; ISOPROPYLAMIDE; tetrabutyl-ammonium chloride; caesium carbonate; sodium hydroxide;
In
water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;