5-Bromo-1-methyl-1H-benzo[d]imidazole

Base Information

• Chemical Name: 5-Bromo-1-methyl-1H-benzo[d]imidazole
• CAS No.: 53484-15-4
• Molecular Formula: C8H7BrN2
• Molecular Weight: 211.061
• Hs Code.: 2933990090
• Mol file: 53484-15-4.mol

Synonyms:1-Methyl-5-bromobenzimidazole;

Chemical Property of 5-Bromo-1-methyl-1H-benzo[d]imidazole

Chemical Property:

• Boiling Point: 317.2±34.0 °C(Predicted)
• PKA: 4.56±0.10(Predicted)
• Flash Point: 145.7 °C
• PSA: 17.82000
• Density: 1.6 g/cm³
• LogP: 2.33580
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-1-methyl-1H-benzo[d]imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-1-methyl-1H-benzo[d]imidazole

There total 9 articles about 5-Bromo-1-methyl-1H-benzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

orthoformic acid triethyl ester (122-51-0) + 2-N-methylamino-5-bromoaniline (69038-76-2) → 5-bromo-1-methyl-1H-benzo[d]imidazole (53484-15-4)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; at 85 ℃; for 2h;

Reference yield: 89.0%

2-N-methylamino-5-bromoaniline (69038-76-2) + trimethyl orthoformate (149-73-5) → 5-bromo-1-methyl-1H-benzo[d]imidazole (53484-15-4)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; at 105 ℃; for 1h;

Reference yield: 88.0%

carbon dioxide (124-38-9,18923-20-1) + 4-Bromo-benzene-1,2-diamine (1575-37-7) → 5-bromo-1-methyl-1H-benzo[d]imidazole (53484-15-4) + 5-bromo-1H-benzo[d]imidazole (4887-88-1)

Guidance literature:

With phenylsilane; at 50 ℃; for 3h; under 22502.3 Torr; Pressure; Autoclave;

DOI:10.1039/d0gc02142c

upstream raw materials:

formic acid

orthoformic acid triethyl ester

2-N-methylamino-5-bromoaniline

trimethyl orthoformate

Downstream raw materials:

N,1-dimethyl-1H-benzo[d]imidazol-5-amine

1-methyl-1H-benzo[d]imidazol-5-amine

Refernces

• 1、 Dong, Yaxi,Breit, Bernhard. "Cu-Catalyzed C-H Allylation of Benzimidazoles with Allenes". supporting information. p. 6765 - 6769. Retrieved 2021/09/11.
• 2、 Dai, Wenshuai,Li, Hu,Saravanamurugan, Shunmugavel,Wu, Hongguo,Yang, Song. "Endogenous X-C=O species enable catalyst-free formylation prerequisite for CO2reductive upgrading". . p. 5822 - 5832. Retrieved 2020/10/21.