7-HYDROXY-1-INDANONE 97

Base Information

• Chemical Name: 7-HYDROXY-1-INDANONE 97
• CAS No.: 6968-35-0
• Molecular Formula: C9H8 O2
• Molecular Weight: 148.161
• Hs Code.: 29145090
• Mol file: 6968-35-0.mol

Synonyms:1-Indanone,7-hydroxy- (6CI,7CI);1-Oxo-7-indanol;7-Hydroxy-1-indanone;7-Hydroxy-2,3-dihydroinden-1-one;NSC 64459;

Chemical Property of 7-HYDROXY-1-INDANONE 97

Chemical Property:

• Vapor Pressure: 0.000332mmHg at 25°C
• Melting Point: 109-113 °C(lit.)
• Refractive Index: 1.631
• Boiling Point: 310.3 ºC at 760 mmHg
• PKA: 10.27±0.20(Predicted)
• Flash Point: 131.3 ºC
• PSA: 37.30000
• Density: 1.305
• LogP: 1.52110
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.0% ^*data from raw suppliers

7-Hydroxy-1-indanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 36/37/38:
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 7-HYDROXY-1-INDANONE 97

There total 25 articles about 7-HYDROXY-1-INDANONE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(para-bromophenyl)-2-propenoate (50663-21-3) → 7-hydroxy-indan-1-one (6968-35-0)

Guidance literature:

With aluminium trichloride; sodium chloride; at 100 - 160 ℃; for 1.25h;

Reference yield: 75.2%

2,3-dihydro-4H-1-benzopyran-4-one (491-37-2) → 7-hydroxy-indan-1-one (6968-35-0)

Guidance literature:

2,3-dihydro-4H-1-benzopyran-4-one; With aluminum (III) chloride; sodium chloride; at 50 - 200 ℃; for 0.333333h;

With hydrogenchloride; at 0 ℃; for 0.5h;

Reference yield: 68.0%

C17H16O7 → 7-hydroxy-indan-1-one (6968-35-0) + dimethyl 3,4-furandicarboxylate (4282-33-1) + 1-hydroxyhomobarrelenone

Guidance literature:

In chlorobenzene; at 120 ℃; for 144h;

DOI:10.1246/bcsj.61.2393

upstream raw materials:

2,3-dihydro-4H-1-benzopyran-4-one

3-(3-hydroxyphenyl)-propanoic acid

phenyl acrylate

3-chloropropionic acid phenyl ester

Downstream raw materials:

7-allyloxyindan-1-one

8-methoxy-3,4-dihydroisoquinolin-1(2H)-one

8-methoxy-1,2,3,4-tetrahydroisoquinoline

4-indanol

Refernces

• 1、 Antkowiak, Roza,Antkowiak, Wieslaw Z.,Czerwi'nski, Grzegorz. "Hindered N-oxides of cavity shaped molecules". . p. 2445 - 2452. Retrieved 1990.
• 2、 Fraaije, Marco,Lon?ar, Nikola,de Gonzalo, Gonzalo. "Kinetic resolution of racemic benzofused alcohols catalysed by HMFO variants in presence of natural deep eutectic solvents". . . Retrieved 2022/03/01.
• 3、 Chen, Lei,Su, Mei,Jin, Qiu,Wang, Wei,Wang, Chun-Gu,Assani, Israa,Wang, Mu-Xuan,Zhao, Shi-Feng,Lv, Shen-Min,Wang, Jia-Wei,Sun, Bo,Li, Yan,Liao, Zhi-Xin. "Discovery of Chromane-6-Sulfonamide Derivative as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist". . p. 16106 - 16131. Retrieved 2021/11/18.