Technology Process of ethyl 2-((2'-benzyl-4'-hydroxy-[1,1'-biphenyl]-4-yl)oxy)acetate
There total 6 articles about ethyl 2-((2'-benzyl-4'-hydroxy-[1,1'-biphenyl]-4-yl)oxy)acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl 2-(4-bromophenoxy)acetate;
With
dichlorobis(tri-O-tolylphosphine)palladium; sodium carbonate; tris-(o-tolyl)phosphine;
In
dichloromethane; water;
at 115 ℃;
for 1h;
Inert atmosphere;
3-benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol;
In
dichloromethane; water;
at 115 ℃;
Inert atmosphere;
DOI:10.1016/j.tet.2012.04.106
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C / Inert atmosphere; Daylight
2.1: boron tribromide / dichloromethane / 20 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere
4.1: dichlorobis(tri-O-tolylphosphine)palladium; sodium carbonate; tris-(o-tolyl)phosphine / dichloromethane; water / 1 h / 115 °C / Inert atmosphere
4.2: 115 °C / Inert atmosphere
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; dichlorobis(tri-O-tolylphosphine)palladium; potassium acetate; boron tribromide; sodium carbonate; tris-(o-tolyl)phosphine;
In
1,4-dioxane; dichloromethane; water; acetonitrile;
4.2: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2012.04.106
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran / 0.5 h / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: dichlorobis(tri-O-tolylphosphine)palladium; sodium carbonate; tris-(o-tolyl)phosphine / dichloromethane; water / 1 h / 115 °C / Inert atmosphere
2.2: 115 °C / Inert atmosphere
With
dichlorobis(tri-O-tolylphosphine)palladium; sodium hydride; sodium carbonate; tris-(o-tolyl)phosphine;
In
tetrahydrofuran; dichloromethane; water;
2.2: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2012.04.106