Isovaline, 3-methyl-, methyl ester (9CI)

Base Information

• Chemical Name: Isovaline, 3-methyl-, methyl ester (9CI)
• CAS No.: 151858-52-5
• Molecular Formula: C7H15 N O2
• Molecular Weight: 145.1995
• Hs Code.: 2922498590
• Mol file: 151858-52-5.mol

Synonyms:Isovaline,3-methyl-, methyl ester (9CI); Methyl 2-amino-2,3-dimethylbutyrate

Chemical Property of Isovaline, 3-methyl-, methyl ester (9CI)

Chemical Property:

• PSA: 52.32000
• LogP: 1.23310

Purity/Quality:

Methyl2-amino-2,3-dimethylbutanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isovaline, 3-methyl-, methyl ester (9CI)

There total 5 articles about Isovaline, 3-methyl-, methyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 2,3-dimethyl-2-nitrobutyrate → α-methylvaline methyl ester (151858-52-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 12h;

DOI:10.1021/jo0709450

Reference yield: 61.0%

methyl 2-(2-benzoyl-2-methylhydrazinyl)-2,3-dimethylbutanoate (1029435-30-0) → α-methylvaline methyl ester (151858-52-5) + N-methylbenzamide (88070-48-8)

Guidance literature:

methyl 2-(2-benzoyl-2-methylhydrazinyl)-2,3-dimethylbutanoate; With samarium diiodide; In tetrahydrofuran; methanol; at -78 - 20 ℃; for 2h; Inert atmosphere;

With acetic acid; In tetrahydrofuran; methanol; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol800733b

Reference yield: 46.0%

methanol (67-56-1) + L-2-amino-2,3-dimethylbutyric acid (26287-62-7) → α-methylvaline methyl ester (151858-52-5)

Guidance literature:

methanol; L-2-amino-2,3-dimethylbutyric acid; With sulfuric acid; Reflux;

With sodium hydrogencarbonate; In water; ethyl acetate;

upstream raw materials:

L-valine methyl ester

Methyl 2-nitro-3-methylbutanoate

methyl 2-(2-benzoyl-2-methylhydrazinyl)-2,3-dimethylbutanoate

methanol

Downstream raw materials:

methyl 2-benzamido-2,3-dimethylbutanoate

Refernces

• 1、 Friestad, Gregory K.,Ji, An. "Mn-mediated coupling of alkyl iodides and ketimines: A radical addition route to α,α-disubstituted α-aminoesters". supporting information; experimental part. p. 2311 - 2313. Retrieved 2009/05/11.