88070-48-8

Basic information

• Product Name: Benzenecarboximidic acid, N-methyl- (9CI)
• Synonyms: Benzenecarboximidic acid, N-methyl- (9CI)
• CAS NO: 88070-48-8
• Molecular Formula: C₈H₉NO
• Molecular Weight: 135.16316
• Product Categories: AMIDE
• Mol File: 88070-48-8.mol
• Article Data: 242

Chemical Properties

• Boiling Point: 254.9±23.0 °C(Predicted)
• Appearance: /
• Density: 1.01±0.1 g/cm3(Predicted)
• PKA: 3.34±0.70(Predicted)
• CAS DataBase Reference: Benzenecarboximidic acid, N-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenecarboximidic acid, N-methyl- (9CI)(88070-48-8)
• EPA Substance Registry System: Benzenecarboximidic acid, N-methyl- (9CI)(88070-48-8)

Safety Data

• Hazardous Substances Data: 88070-48-8(Hazardous Substances Data)

Upstream product

• 3376-23-6 N-methyl-α-phenylnitrone 
• 108-24-7 acetic anhydride 
• 60-29-7 diethyl ether 
• 13381-65-2 α-Bromobenzyl benzoate 
• 74-89-5 methylamine 
• 7471-86-5 methyl benzimidate 
• 74-88-4 methyl iodide 
• 495-69-2 Hippuric Acid 
• 16155-60-5 5-phenyl-2-p-tolyloxazole 
• 33675-68-2 N-(4-methoxyphenyl)-N-methyl-benzamide 
• 2568-34-5 N-benzoyl-N-methylglycine 
• 65178-52-1 N-allyl-N-methylbenzamide 
• 106-99-0 buta-1,3-diene 
• 99160-15-3 C₁₂H₂₄O₆*CH₅N*ClH 

Downstream Products

• 20743-50-4 1-methyl-5-phenyltetrazole 
• 3400-26-8 N-methyl-3-nitro-benzamide 
• 5310-14-5 N-methylthiobenzamide 
• 5014-48-2 N-chloro-N-methylbenzamide 
• 63412-06-6 N-methyl-N-nitrosobenzamide 
• 2397-29-7 N-methyl-N'-phenylbenzamidine 
• 15994-87-3 N-(4-chloro-phenyl)-N'-methyl-benzamidine 
• 21737-87-1 N-methyl benzimidoyl chloride 
• 103-67-3 benzyl-methyl-amine 
• 29019-38-3 N,N'-dimethylbenzoamidine 
• 65-85-0 benzoic acid 
• 51164-42-2 N-chloromethyl-N-methylbenzamide 
• 141264-25-7 N-Formyl-N-methylbenzamide 
• 2397-29-7 N-methyl-N′-phenylbenzimidamide 

Relevant articles and documents

Generation of Oxyphosphonium Ions by Photoredox/Cobaloxime Catalysis for Scalable Amide and Peptide Synthesis in Batch and Continuous-Flow

Phosphine-mediated deoxygenative nucleophilic substitutions, such as the Mitsunobu reaction, are of great importance in organic synthesis. However, the conventional protocols require stoichiometric oxidants to trigger the formation of the oxyphosphonium i

AMINE-BORANES AS BIFUNCTIONAL REAGENTS FOR DIRECT AMIDATION OF CARBOXYLIC ACIDS

The present invention generally relates to a process for selective and direct activation and subsequent amidation of aliphatic and aromatic carboxylic acids to afford an amide R3CONR1R2. That the process is capable of delivering gaseous or low-boiling point amines provides a major advantage over existing methodologies, which involves an intermediate of triacyloxyborane-amine complex [(R3CO2)3—B—NHR1R2]. This procedure readily produces primary, secondary, and tertiary amides, and is compatible with the chirality of the acid and amine involved. The preparation of known pharmaceutical molecules and intermediates has also been demonstrated.

Photocatalysis in Aqueous Micellar Media Enables Divergent C-H Arylation and N-Dealkylation of Benzamides

Photocatalysis in aqueous micellar media has recently opened wide avenues to activate strong carbon-halide bonds. So far, however, it has mainly explored strongly reducing conditions, restricting the available chemical space to radical or anionic reactivity. Here, we demonstrate a controllable, photocatalytic strategy that channels the reaction of chlorinated benzamides via either a radical or a cationic pathway, enabling a chemodivergent C-H arylation or N-dealkylation. The catalytic system operates under mild conditions with methylene blue as a photocatalyst and blue LEDs as the light source. Factors determining the reactivity of substrates, their selectivity, and preliminary mechanistic studies are presented.