Simvastatin Dimer

Base Information

• Chemical Name: Simvastatin Dimer
• CAS No.: 476305-24-5
• Molecular Formula: C50H76O10
• Molecular Weight: 837.147
• Hs Code.: 29322090
• Mol file: 476305-24-5.mol

Synonyms:Simvastatin Dimer;Simvastatin Impurity;Simvastatin Impurity D

Chemical Property of Simvastatin Dimer

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 170-180?C
• Refractive Index: 1.547
• Boiling Point: 882.067°C at 760 mmHg
• PKA: 14.01±0.20(Predicted)
• Flash Point: 245.705°C
• PSA: 72.83000
• Density: 1.141g/cm³
• LogP: 4.58560
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

SimvastatinDimer ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Simvastatin Dimer Impurity (Simvastatin EP Impurity D) is an impurity of Simvastatin (Dimer). An impurity of Simvastatin (Dimer)

Technology Process of Simvastatin Dimer

There total 4 articles about Simvastatin Dimer which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.4%

simvastatin ammonium salt (139893-43-9) → C50H76O10 (476305-24-5) + simvastatin (123049-81-0,79902-63-9)

Guidance literature:

In xylenes; at 138 - 140 ℃; for 0.5h;

Reference yield: 70.0%

C53H80O10 → C50H76O10 (476305-24-5)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 4h;

Reference yield:

simvastatin (123049-81-0,79902-63-9) → C50H76O10 (476305-24-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: calcium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

2.1: 0.08 h

2.2: 20 °C

3.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 1 h / 20 °C

4.1: hydrogenchloride / water / 4 h / 20 °C

With hydrogenchloride; dmap; water; dicyclohexyl-carbodiimide; calcium hydroxide; In tetrahydrofuran; dichloromethane; water;

upstream raw materials:

simvastatin ammonium salt

simvastatin

simvastatin acid

Refernces

• 1、 -. "Process for lactonization to produce simvastatin". Page 3. . Retrieved 2010/02/05.