2-Bromo-4-chlorobenzonitrile

Base Information

• Chemical Name: 2-Bromo-4-chlorobenzonitrile
• CAS No.: 57381-49-4
• Molecular Formula: C7H3BrClN
• Molecular Weight: 216.465
• Hs Code.: 2926907090
• Mol file: 57381-49-4.mol

Synonyms:Benzonitrile, 2-bromo-4-chloro-;

Chemical Property of 2-Bromo-4-chlorobenzonitrile

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.623
• Boiling Point: 284.001 °C at 760 mmHg
• Flash Point: 125.56 °C
• PSA: 23.79000
• Density: 1.74 g/cm³
• LogP: 2.97418
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-4-chlorobenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-4-chlorobenzonitrile

There total 6 articles about 2-Bromo-4-chlorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-bromo-4-chlorobenzamide (131002-01-2) → 2-bromo-4-chloro-benzonitrile (57381-49-4)

Guidance literature:

With thionyl chloride; for 5.5h; Heating;

DOI:10.1002/(sici)1521-3897(200002)342:2<201::aid-prac201>3.3.co;2-c

Reference yield: 57.0%

2-bromo-4-chlorobenzoic acid (936-08-3) → 2-bromo-4-chloro-benzonitrile (57381-49-4)

Guidance literature:

With aluminum oxide; urea; at 150 ℃; for 1h; Microwave irradiation;

Reference yield:

1-(2-bromo-4-chlorophenyl)-N-hydroxymethanimine (1379427-96-9) → 2-bromo-4-chloro-benzonitrile (57381-49-4)

Guidance literature:

With acetic anhydride; potassium carbonate; In dimethyl sulfoxide; at 50 ℃;

DOI:10.1039/c8ob02288g

upstream raw materials:

2-bromo-4-chlorobenzamide

2-bromo-4-chlorobenzoic acid

4-Cyanochlorobenzene

1-(2-bromo-4-chlorophenyl)-N-hydroxymethanimine

Downstream raw materials:

3-amino-6-chloro-1H-indazole

2-bromo-4-hydrazinylbenzonitrile

4-chloro-N-phenyl phthalimide

2-bromo-4-morpholinobenzonitrile

Refernces

• 1、 -. "SUBSTITUTED QUINOLONES III". Page/Page column 9-10. . Retrieved 2009/07/25.
• 2、 -. "Substituted quinolones II". Page/Page column 9. . Retrieved 2008/12/04.