2-bromo-4-morpholinobenzonitrile

Base Information

• Chemical Name: 2-bromo-4-morpholinobenzonitrile
• CAS No.: 1129540-63-1
• Molecular Formula: C₁₁H₁₁BrN₂O
• Molecular Weight: 267.125
• Mol file: 1129540-63-1.mol

Synonyms:2-bromo-4-morpholinobenzonitrile

Chemical Property of 2-bromo-4-morpholinobenzonitrile

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

2-Bromo-4-morpholinobenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-4-morpholinobenzonitrile

There total 3 articles about 2-bromo-4-morpholinobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

morpholine (110-91-8,99108-56-2) + 2-bromo-4-chloro-benzonitrile (57381-49-4) → 2-bromo-4-morpholinobenzonitrile (1129540-63-1)

Guidance literature:

With potassium carbonate; triethylamine; In N,N-dimethyl-formamide; at 115 ℃; for 48h; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.1c05281

Reference yield:

4-Cyanochlorobenzene (623-03-0) → 2-bromo-4-morpholinobenzonitrile (1129540-63-1)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; N-Bromosuccinimide; toluene-4-sulfonic acid / 1,2-dichloro-ethane / 16 h / 70 °C / Sealed tube

2: potassium carbonate; triethylamine / N,N-dimethyl-formamide / 48 h / 115 °C / Inert atmosphere; Sealed tube

With N-Bromosuccinimide; palladium diacetate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1021/jacs.1c05281

Reference yield:

→ 2-bromo-4-morpholinobenzonitrile (1129540-63-1)

Guidance literature:

upstream raw materials:

4-Cyanochlorobenzene

morpholine

2-bromo-4-chloro-benzonitrile

Downstream raw materials:

2-(2-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenylamino)pyrimidin-4-yl)-4-morpholinobenzonitrile

Refernces

• 1、 -. "SUBSTITUTED PYRIMIDINYL-AMINES AS PROTEIN KINASE INHIBITORS". Page/Page column 68. . Retrieved 2009/04/25.