w-Bromo-4-Hydroxyacetophenone

Base Information

• Chemical Name: w-Bromo-4-Hydroxyacetophenone
• CAS No.: 53946-87-5
• Molecular Formula: C9H10BrO2
• Molecular Weight: 229.073
• Hs Code.: 2914700090
• Mol file: 53946-87-5.mol

Synonyms:2-Bromo-1-(4-hydroxyphenyl)propan-1-one;

Chemical Property of w-Bromo-4-Hydroxyacetophenone

Chemical Property:

• Vapor Pressure: 4.72E-05mmHg at 25°C
• Refractive Index: 1.59
• Boiling Point: 339.3 °C at 760 mmHg
• Flash Point: 159 °C
• PSA: 37.30000
• Density: 1.532 g/cm³
• LogP: 2.35830
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98.0%Min ^*data from raw suppliers

2-Bromo-1-(4-hydroxyphenyl)propan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of w-Bromo-4-Hydroxyacetophenone

There total 6 articles about w-Bromo-4-Hydroxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-hydroxypropiophenone (70-70-2) → 2-bromo-(4'-hydroxyphenyl)-propan-1-one (53946-87-5)

Guidance literature:

With pyridinium hydrobromide perbromide; acetic acid; at 20 ℃; for 3.08333h; Product distribution / selectivity;

Reference yield: 69.0%

α-bromopropionyl bromide (563-76-8) + phenol (108-95-2,27073-41-2) → 2-bromo-(4'-hydroxyphenyl)-propan-1-one (53946-87-5)

Guidance literature:

With trifluorormethanesulfonic acid; In neat (no solvent); at 0 - 20 ℃; for 1.08333h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c01912

Reference yield:

phenyl 2-bromopropionate (42710-26-9) → 2-bromo-(4'-hydroxyphenyl)-propan-1-one (53946-87-5)

Guidance literature:

With aluminium trichloride; at 125 ℃;

upstream raw materials:

4-hydroxypropiophenone

phenyl 2-bromopropionate

phenol

α-bromopropionyl bromide

Downstream raw materials:

4-hydroxypropiophenone

(+/-)-Erythro-Ifenprodil

(+/-)-Threo-Ifenprodil

(RS)-2-(4-benzylpiperidin-1-yl)-1-(4-hydroxyphenyl)propan-1-one

Refernces

• 1、 Chen, Wenbin,Wang, Lei,Liu, Xinyue,Chen, Bo,Zhao, Guofeng. "Synthesis and preliminary photopolymerization evaluation of novel photoinitiators containing phototrigger to overcome oxygen inhibition in the UV- curing system". . . Retrieved 2019/11/26.
• 2、 Moon, Da Yoon,An, Sejin,Park, Bong Ser. "Synthesis of α,β-dibromo ketones by photolysis of α-bromo ketones with N-bromosuccinimide: Photoinduced β-bromination of α-bromo ketones". . . Retrieved 2019/10/28.