A-1-(AMINOMETHYL)-4-HYDROXY-1,3-BENZENDIMETHANOL

Base Information

• Chemical Name: A-1-(AMINOMETHYL)-4-HYDROXY-1,3-BENZENDIMETHANOL
• CAS No.: 24085-19-6
• Molecular Formula: C9H13 N O3
• Molecular Weight: 183.207
• Hs Code.: 2922509090
• Mol file: 24085-19-6.mol

Synonyms:m-Xylene-a,a'-diol, a1-(aminomethyl)-4-hydroxy- (8CI);2-(4-Hydroxy-3-hydroxymethylphenyl)-2-hydroxyethylamine;2-Amino-1-(4-hydroxy-3-hydroxymethylphenyl)ethanol; a1-Aminomethyl-4-hydroxy-m-xylene-a1,a3-diol

Chemical Property of A-1-(AMINOMETHYL)-4-HYDROXY-1,3-BENZENDIMETHANOL

Chemical Property:

• Boiling Point: 415.4±30.0 °C(Predicted)
• PKA: 9.98±0.31(Predicted)
• PSA: 86.71000
• Density: 1.342±0.06 g/cm3(Predicted)
• LogP: 0.57690

Purity/Quality:

99% ^*data from raw suppliers

4-(2-AMINO-1-HYDROXYETHYL)-2-(HYDROXYMETHYL)PHENOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of A-1-(AMINOMETHYL)-4-HYDROXY-1,3-BENZENDIMETHANOL

There total 5 articles about A-1-(AMINOMETHYL)-4-HYDROXY-1,3-BENZENDIMETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-α1-[[bis(phenylmethyl)amino]methyl]-1,3-benzenedimethanol (24085-32-3) → 2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)-ethanamine (24085-19-6)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1021/jm00298a022

Reference yield:

methyl-5-(N,N-dibenzylglycyl) salicylate (36270-04-9) → 2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)-ethanamine (24085-19-6)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄

2: H₂ / Pd-C

With lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal;

DOI:10.1021/jm00298a022

Reference yield:

estere metilico dell'acido 5-acetilsalicilico (16475-90-4) → 2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)-ethanamine (24085-19-6)

Guidance literature:

Multi-step reaction with 4 steps

1: Br₂

3: LiAlH₄

4: H₂ / Pd-C

With lithium aluminium tetrahydride; hydrogen; bromine; palladium on activated charcoal;

DOI:10.1021/jm00298a022

upstream raw materials:

4-hydroxy-α1-[[bis(phenylmethyl)amino]methyl]-1,3-benzenedimethanol

methyl-5-(N,N-dibenzylglycyl) salicylate

estere metilico dell'acido 5-acetilsalicilico

3-carbomethoxy-4-hydroxy-α-bromoacetophenone

Downstream raw materials:

N-[2-(4-(1-carboethoxy)ethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl) ethanamine

α¹-(Cyclopentylaminomethyl)-4-hydroxy-m-xylol-α¹,α³-diol

Refernces

• 1、 Collin,Hartley,Jack,Lunts,Press,Ritchie,Toon. "Saligenin analogs of sympathomimetic catecholamines.". . p. 674 - 680. Retrieved 2007/10/04.