16475-90-4Relevant articles and documents
Energy efficiency in chemical reactions: A comparative study of different reaction techniques
Gronnow, Mark J.,White, Robin J.,Clark, James H.,Macquarrie, Duncan J.
, p. 516 - 518 (2005)
Metrics for chemists are much argued, but the energy usage of a reaction has to be one of the most simple and effective methods of comparing technologies. In this concept paper, the energy consumed in preparing one mole of a chemical compound is compared for a variety of technologies. Data are gathered for traditional oil bath, supercritical CO2 (sc-CO 2), and microwave reactors. Two different Suzuki couplings, a Knoevenagel condensation, and a Friedel-Crafts acylation are all compared in both the microwave and oil bath, as this is where the most noticeable differences were observed. The most notable result was an 85-fold reduction in energy demand on switching from oil bath to microwave reactor for a Suzuki reaction.
Enantioselective bromolactonization of conjugated (2)-enynes
Zhang, Wei,Zheng, Suqing,Liu, Na,Werness, Jenny B.,Guzei, Llia A.,Tang, Weiplng
supporting information; experimental part, p. 3664 - 3665 (2010/05/15)
"Chemical equation presented" A catalytic enantioselective syn-1,4-bromolactonization of conjugated (Z)-enynes was reported. Diastereomeric ratios >20:1 and up to 99% enantiomeric excesses were observed. Di-, tri-, and tetra-substituted bromoallenes were prepared together with lactone heterocycles efficiently and stereoselectively. Preliminary investigations suggest that the chiral catalyst may serve as a bifunctional reagent by interacting with both a carboxylic acid nucleophile and NBS electrophile.
Alternative routes to pterulone
Kahnberg, Pia,Lee, Choon Woo,Grubbs, Robert H,Sterner, Olov
, p. 5203 - 5208 (2007/10/03)
Two new synthetic routes to pterulone, a fungal metabolite possessing potent antifungal activity as an inhibitor of NADH/ubiquinone oxidoreductase, are reported.