METHYL-4-BROMO-3-CHLOROBENZOATE

Base Information

• Chemical Name: METHYL-4-BROMO-3-CHLOROBENZOATE
• CAS No.: 117738-74-6
• Molecular Formula: C8H6 Br Cl O2
• Molecular Weight: 249.491
• Hs Code.: 2916399090
• Mol file: 117738-74-6.mol

Synonyms:4-Bromo-3-chlorobenzoicacid methyl ester

Chemical Property of METHYL-4-BROMO-3-CHLOROBENZOATE

Chemical Property:

• Melting Point: 57.0 to 61.0 °C
• Boiling Point: 309.1±22.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.604±0.06 g/cm3(Predicted)
• LogP: 2.88910
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

Methyl 4-Bromo-3-chlorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 4-Bromo-3-chlorobenzoate is used as a reactant in the preparation of oxopyrrolidinylaminobenzenecarbohydroxamic acids as histone deacetylase inhibitors.

Technology Process of METHYL-4-BROMO-3-CHLOROBENZOATE

There total 2 articles about METHYL-4-BROMO-3-CHLOROBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

chloro-trimethyl-silane (75-77-4) + 4-bromo-3-chlorobenzoic acid (25118-59-6) → methyl 4-bromo-3-chlorobenzoate (117738-74-6)

Guidance literature:

In methanol; at 20 ℃;

Reference yield:

sodium metabisulfite + copper(ll) sulfate pentahydrate + methyl 4-amino-3-chlorobenzoate (84228-44-4) → methyl 4-bromo-3-chlorobenzoate (117738-74-6)

Guidance literature:

With sodium hydroxide; sodium bromide; sodium nitrite; In water; hydrogen bromide;

Reference yield: 100.0%

5-Amino-2-methylpyridine (80287-53-2,3430-14-6) + methyl 4-bromo-3-chlorobenzoate (117738-74-6) → 3-chloro-4-(6-methyl-pyridin-3-ylamino)-benzoic acid methyl ester (1072930-83-6)

Guidance literature:

With potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 80 ℃; for 16h;

upstream raw materials:

methyl 4-amino-3-chlorobenzoate

chloro-trimethyl-silane

4-bromo-3-chlorobenzoic acid

Downstream raw materials:

4-bromo-3-chlorobenzoic acid

3-chloro-4-(6-methyl-pyridin-3-ylamino)-benzoic acid methyl ester

4-[1-benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indol-5-yl]-3-chloro-benzoic acid methyl ester

4-n-butyl-3-chlorobenzoic acid

Refernces

• 1、 -. "Pesticidal compounds". . . Retrieved 2008/06/13.