6-BROMO-4-IODOQUINOLINE

Base Information

• Chemical Name: 6-BROMO-4-IODOQUINOLINE
• CAS No.: 927801-23-8
• Molecular Formula: C9H5BrIN
• Molecular Weight: 333.954
• Hs Code.: 2933491090
• Mol file: 927801-23-8.mol

Synonyms:6-Bromo-4-iodoquinoline ; quinoline, 6-bromo-4-iodo-; T66 BNJ EI HE; LogP

Chemical Property of 6-BROMO-4-IODOQUINOLINE

Chemical Property:

• Vapor Pressure: 1.67E-05mmHg at 25°C
• Refractive Index: 1.744
• Boiling Point: 375.5 °C at 760 mmHg
• Flash Point: 180.9 °C
• PSA: 12.89000
• Density: 2.154 g/cm³
• LogP: 3.60190
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromo-4-iodoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMO-4-IODOQUINOLINE

There total 6 articles about 6-BROMO-4-IODOQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-bromo-4-chloroquinoline (65340-70-7) → 6-bromo-4-iodoquinoline (927801-23-8)

Guidance literature:

6-bromo-4-chloroquinoline; With hydrogenchloride; In diethyl ether; water;

With sodium iodide; In diethyl ether; water; propiononitrile; Reflux;

DOI:10.1021/ml900028r

Reference yield: 94.0%

6-bromo-4-chloroquinoline hydrochloride (1086062-75-0) → 6-bromo-4-iodoquinoline (927801-23-8)

Guidance literature:

With potassium iodide; In acetonitrile; for 48h; Reflux;

DOI:10.1016/j.ejmech.2015.05.025

Reference yield:

5-(((4-bromophenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (187278-01-9) → 6-bromo-4-iodoquinoline (927801-23-8)

Guidance literature:

Multi-step reaction with 4 steps

1: diphenylether / 0.25 h / 245 - 250 °C / Inert atmosphere

2: trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux

3: hydrogenchloride / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C

4: sodium iodide / propiononitrile / 96 h / Reflux

With hydrogenchloride; diphenylether; sodium iodide; trichlorophosphate; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; propiononitrile;

DOI:10.1016/j.bmcl.2011.12.136

upstream raw materials:

6-bromo-4-chloroquinoline

6-bromo-4-chloroquinoline hydrochloride

6-bromo-3-quinolinecarboxylic acid-4-ol

5-(((4-bromophenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Downstream raw materials:

GS⁽²⁶⁴⁾K₂₁₅₈

4-fluoro-N-(2-methoxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)-2-nitrobenzenesulfonamide

2-fluoro-N-(2-methoxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)-4-nitrobenzenesulfonamide

2,4-difluoro-N-(2-hydroxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide

Refernces

• 1、 -. "1,2,4-TRIAZINE-3-AMINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE". Paragraph 0125; 0274; 0275. . Retrieved 2019/11/28.
• 2、 -. "PI3 kinase modulators and methods of use thereof, and use thereof". . . Retrieved 2016/10/07.