4-Fluoro-1-methylindazole

Base Information

• Chemical Name: 4-Fluoro-1-methylindazole
• CAS No.: 1092961-07-3
• Molecular Formula: C8H7FN2
• Molecular Weight: 150.153
• Hs Code.: 2933998090
• Mol file: 1092961-07-3.mol

Synonyms:4-fluoro-1-methyl-indazole;4-fluoro-1-methyl-1H-indazole;1H-indazole, 4-fluoro-1-methyl-;

Chemical Property of 4-Fluoro-1-methylindazole

Chemical Property:

• Boiling Point: 236.1 °C at 760 mmHg
• PKA: 0.76±0.30(Predicted)
• Flash Point: 96.6 °C
• PSA: 17.82000
• Density: 1.23 g/cm³
• LogP: 1.71240
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Fluoro-1-methyl-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluoro-1-methylindazole

There total 4 articles about 4-Fluoro-1-methylindazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-amino-1-methyl-4-fluoro-1H-indazole (162502-44-5) → 4-fluoro-1-methyl-1H-indazole (1092961-07-3)

Guidance literature:

With tert.-butylnitrite; In tetrahydrofuran; for 1h; Reflux;

DOI:10.1016/j.tet.2013.03.042

Reference yield: 90.0%

4-bromo-1-methyl-1H-indazole (365427-30-1) → 4-fluoro-1-methyl-1H-indazole (1092961-07-3)

Guidance literature:

With potassium fluoride; C₁₁₄H₁₅₈O₄P₂Pd₂; silver fluoride; In tert-butyl methyl ether; at 110 ℃; for 14h; Sealed tube;

DOI:10.1021/ja5009739

Reference yield: 53.0%

4-fluoro-1H-indazole (341-23-1) + methyl iodide (74-88-4) → 4-fluoro-1-methyl-1H-indazole (1092961-07-3)

Guidance literature:

With potassium hydroxide; In acetone; at 0 - 20 ℃; for 18h;

DOI:10.1021/jacs.7b03131

upstream raw materials:

2,6 difluorobenzonitrile

3-amino-1-methyl-4-fluoro-1H-indazole

4-bromo-1-methyl-1H-indazole

4-fluoro-1H-indazole

Refernces

• 1、 Lee, Hong Geun,Milner, Phillip J.,Buchwald, Stephen L.. "Pd-catalyzed nucleophilic fluorination of aryl bromides". supporting information. p. 3792 - 3795. Retrieved 2014/04/03.