N-(3,5-Dichlorophenyl)acetamide

Base Information

• Chemical Name: N-(3,5-Dichlorophenyl)acetamide
• CAS No.: 31592-84-4
• Molecular Formula: C8H7 Cl2 N O
• Molecular Weight: 204.056
• Hs Code.: 2924299090
• Mol file: 31592-84-4.mol

Synonyms:Acetanilide,3',5'-dichloro- (7CI,8CI); 3,5-Dichloroacetanilide;N-(3,5-Dichlorophenyl)acetamide; NSC 83301

Chemical Property of N-(3,5-Dichlorophenyl)acetamide

Chemical Property:

• Vapor Pressure: 3.34E-05mmHg at 25°C
• Boiling Point: 354.5°C at 760 mmHg
• Flash Point: 168.2°C
• PSA: 29.10000
• Density: 1.393g/cm³
• LogP: 3.02480

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3,5-Dichlorophenyl)acetamide

There total 10 articles about N-(3,5-Dichlorophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

acetic anhydride (108-24-7) + 3,5-Dichloroaniline (626-43-7) → N-(3,5-dichlorophenyl)-acetamide (31592-84-4)

Guidance literature:

In acetonitrile; at 100 ℃; for 2h;

DOI:10.1002/(sici)1099-0682(199912)1999:12<2319::aid-ejic2319>3.0.co;2-1

Reference yield: 81.0%

acetonitrile (75-05-8,26809-02-9) + (3,5-dichlorophenyl)boronic acid (67492-50-6) → N-(3,5-dichlorophenyl)-acetamide (31592-84-4)

Guidance literature:

With water; copper(II) bis(trifluoromethanesulfonate); at 90 ℃; for 3h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.202016811

Reference yield: 75.0%

ethyl acetate (141-78-6) + 3,5-Dichloroaniline (626-43-7) → N-(3,5-dichlorophenyl)-acetamide (31592-84-4)

Guidance literature:

With ytterbium(III) triflate; for 5h; Heating;

upstream raw materials:

acetic anhydride

acetic acid

3,5-Dichloroaniline

acetyl chloride

Downstream raw materials:

(3,5-dichlorophenyl)phenylamine

3,5-dichloro-2-nitroaniline

2,6-dichloro-4-aminonitrobenzene

acetic acid-(3,5-dichloro-4-nitro-anilide)

Refernces

• 1、 Bell, Nicola L.,Xu, Chao,Fyfe, James W. B.,Vantourout, Julien C.,Brals, Jeremy,Chabbra, Sonia,Bode, Bela E.,Cordes, David B.,Slawin, Alexandra M. Z.,McGuire, Thomas M.,Watson, Allan J. B.. "Cu(OTf)2-Mediated Cross-Coupling of Nitriles and N-Heterocycles with Arylboronic Acids to Generate Nitrilium and Pyridinium Products**". supporting information. p. 7935 - 7940. Retrieved 2021/03/03.
• 2、 Zhou, Xiao-Yu,Chen, Xia,Yang, Dan. "Iodine and Br?nsted acid catalyzed C–C bond cleavage of 1,3-diketones for the acylation of amines". supporting information. p. 177 - 184. Retrieved 2019/11/26.