2-ISOPROXYPYRIDINE-5-BORONIC ACID

Base Information

• Chemical Name: 2-ISOPROXYPYRIDINE-5-BORONIC ACID
• CAS No.: 870521-30-5
• Molecular Formula: C8H12BNO3
• Molecular Weight: 180.9968
• Hs Code.: 2933399090
• Mol file: 870521-30-5.mol

Synonyms:2-ISOPROXYPYRIDINE-5-BORONIC ACID;6-Isopropoxypyridine-3-boronic acid;[6-(propan-2-yloxy)pyridin-3-yl]boronic acid;6-Isopropoxypyridin-3-boronic acid;(6-Isopropoxy-3-pyridyl)boronic acid;2-Isopropoxy-5-pyridineboronic acid;6-Isoproxypyridine-3-boronic acid

Chemical Property of 2-ISOPROXYPYRIDINE-5-BORONIC ACID

Chemical Property:

• Boiling Point: 325.498 °C at 760 mmHg
• PKA: 7.08±0.18(Predicted)
• Flash Point: 150.656 °C
• PSA: 62.58000
• Density: 1.161g/cm³
• LogP: -0.45140
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

2-Isoproxypyridine-5-boronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ISOPROXYPYRIDINE-5-BORONIC ACID

There total 4 articles about 2-ISOPROXYPYRIDINE-5-BORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

5-bromo-2-isopropoxy-pyridine (870521-31-6) → (6?isopropoxypyridin-3-yl)boronic acid (870521-30-5)

Guidance literature:

5-bromo-2-isopropoxy-pyridine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 2h; Inert atmosphere;

With Triisopropyl borate; In diethyl ether; hexane; at -78 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm9007399

Reference yield:

5-bromo-2-isopropoxy-pyridine (870521-31-6) + Triisopropyl borate (5419-55-6) → (6?isopropoxypyridin-3-yl)boronic acid (870521-30-5)

Guidance literature:

5-bromo-2-isopropoxy-pyridine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 2h;

Triisopropyl borate; In diethyl ether; hexane; at -78 - 20 ℃; for 2h;

With water; In diethyl ether; hexane; at 20 ℃;

Reference yield:

5-bromo-2-isopropoxy-pyridine (870521-31-6) + water (7732-18-5) + bis(pinacol)diborane (73183-34-3) → (6?isopropoxypyridin-3-yl)boronic acid (870521-30-5)

Guidance literature:

5-bromo-2-isopropoxy-pyridine; bis(pinacol)diborane; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 80 ℃; for 16h; Inert atmosphere;

water; In 1,4-dioxane; Inert atmosphere;

upstream raw materials:

5-bromo-2-isopropoxy-pyridine

Triisopropyl borate

water

bis(pinacol)diborane

Downstream raw materials:

C₂₉H₂₇F₃N₂O₇

Refernces

• 1、 Epple, Robert,Cow, Christopher,Xie, Yongping,Azimioara, Mihai,Russo, Ross,Wang, Xing,Wityak, John,Karanewsky, Donald S.,Tuntland, Tove,Nguyê?-Tran, Van T. B.,Ngo, Cara Cuc,Huang, David,Saez, Enrique,Spalding, Tracy,Gerken, Andrea,Iskandar, Maya,Seidel, H. Martin,Tian, Shin-Shay. "Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor δ agonists". experimental part. p. 77 - 105. Retrieved 2010/04/30.
• 2、 -. "COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS". Page/Page column 52-53. . Retrieved 2010/02/14.