5-Bromo-2-isopropoxypyridine

Base Information

• Chemical Name: 5-Bromo-2-isopropoxypyridine
• CAS No.: 870521-31-6
• Molecular Formula: C8H10BrNO
• Molecular Weight: 216.077
• Hs Code.: 2933399090
• Mol file: 870521-31-6.mol

Synonyms:Pyridine, 5-bromo-2-(1-methylethoxy)-;5-Bromo-2-(propan-2-yloxy)pyridine;

Chemical Property of 5-Bromo-2-isopropoxypyridine

Chemical Property:

• Vapor Pressure: 0.111mmHg at 25°C
• Melting Point: 45.61 °C (Mean or Weighted MP)
• Refractive Index: 1.526
• Boiling Point: 228.345 °C at 760 mmHg
• PKA: 1.88±0.22(Predicted)
• Flash Point: 91.9 °C
• PSA: 22.12000
• Density: 1.383 g/cm³
• LogP: 2.63130
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-2-isopropoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Bromo-2-isopropylpyridine is used to prepare azepino[4,?5-?b]?indoles as histamine receptor modulators for treating cognitive and psychotic disorders.

Technology Process of 5-Bromo-2-isopropoxypyridine

There total 10 articles about 5-Bromo-2-isopropoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-bromo-2-fluoropyridine (766-11-0) + isopropyl alcohol (67-63-0,8013-70-5) → 5-bromo-2-isopropoxy-pyridine (870521-31-6)

Guidance literature:

isopropyl alcohol; With sodium hydride; at 25 ℃; for 16h;

5-bromo-2-fluoropyridine; In N,N-dimethyl-formamide; isopropyl alcohol; at 130 ℃; for 4h;

DOI:10.1021/jm060484v

Reference yield: 92.0%

5-bromo-2-fluoropyridine (766-11-0) → 5-bromo-2-isopropoxy-pyridine (870521-31-6)

Guidance literature:

isopropyl alcohol; With sodium hydride; at 25 ℃; for 16.0833h;

5-bromo-2-fluoropyridine; In N,N-dimethyl-formamide; at 130 ℃; for 4.16667h;

Reference yield: 78.0%

5-bromo-2-chloropyridine (53939-30-3) + isopropyl alcohol (67-63-0,8013-70-5) → 5-bromo-2-isopropoxy-pyridine (870521-31-6)

Guidance literature:

isopropyl alcohol; With sodium hydride; In mineral oil; at 60 ℃; for 0.5h; Inert atmosphere;

5-bromo-2-chloropyridine; In mineral oil; at 80 ℃; Reflux;

upstream raw materials:

5-bromo2-nitropyridine

sodium isopropylate

5-bromo-2-fluoropyridine

isopropyl alcohol

Downstream raw materials:

(6?isopropoxypyridin-3-yl)boronic acid

Refernces

• 1、 -. "NOVEL SUBSTITUTED BIARYL COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS". Paragraph 1216-1217. . Retrieved 2019/05/24.
• 2、 -. "SULFONAMIDE COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNEL MODULATORS". Page/Page column 71. . Retrieved 2017/03/28.