Technology Process of 6-Benzofurancarboxylic acid, 4-hydroxy-2-methyl-, methyl ester
There total 1 articles about 6-Benzofurancarboxylic acid, 4-hydroxy-2-methyl-, methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide;
at 24 ℃;
for 25h;
under 1018.63 Torr;
Inert atmosphere;
DOI:10.1021/op900263b
- Guidance literature:
-
With
water; sodium hydroxide;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sodium hydroxide; water / methanol; tetrahydrofuran / 12 h / 20 °C
2: thionyl chloride / 12 h / 20 °C
3: ammonium hydroxide / dichloromethane / 2 h / 20 °C
4: trichlorophosphate / toluene / 12 h / 120 °C
5: pyridine / dichloromethane / 1 h / 0 - 20 °C
6: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate / N,N-dimethyl-formamide; water / 5 h / 90 °C / Inert atmosphere
7: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
With
pyridine; ammonium hydroxide; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; water; potassium carbonate; trifluoroacetic acid; sodium hydroxide; trichlorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
6: |Suzuki Coupling;
