Unii-4bmh7izt98

Base Information

• Chemical Name: Unii-4bmh7izt98
• CAS No.: 856676-23-8
• Molecular Formula: C22H28ClNO5
• Molecular Weight: 421.921
• Hs Code.: 2923100000
• Mol file: 856676-23-8.mol

Synonyms:Fenofibrate Choline;Choline fenofibrate [USAN];2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid;2-Hydroxy-N,N,N-trimethylethanaminium 2-(-(4-chlorobenzoyl)phenoxy)-2- methylpropanoate;ABT 335;ABT-335;Fenofibrate de choline;Trilipix;UNII-4BMH7IZT98;Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with 2-(4-(4- chlorobenzoyl)phenoxy)-2-methylpropanoic acid (1:1);

Chemical Property of Unii-4bmh7izt98

Chemical Property:

• Vapor Pressure: 2.82E-10mmHg at 25°C
• Melting Point: 210-212°C
• Boiling Point: 486.5 °C at 760 mmHg
• Flash Point: 248 °C
• PSA: 86.66000
• LogP: 2.16320
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

CholineFenofibrate;ABT-335 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Choline fenofibrate, a salt formulation of fenofibric acid, is a lipid regulating agent available as delayed release capsules for oral administration. It is indicated in combination with a statin to reduce TG and increase high-density lipoprotein cholesterol (HDL-C) in patients with mixed dyslipidemia and coronary heart disease (CHD) or a CHD-risk equivalent who are optimal for statin therapy to achieve their lowdensity lipoprotein cholesterol (LDL-C) goal. In addition, choline fenofibrate is indicated as monotherapy in patients with severe hypertriglyceridemia to reduce TG, and in patients with primary hyperlipidemia or mixed dyslipidemia to reduce elevated LDL-C, total cholesterol, TG, apolipoprotein B, and to increase HDL-C. Fenofibric acid is also the active metabolite of fenofibrate (Tricor), which has been previously marketed for the treatment of hypercholesterolemia and hypertriglyceridemia. The primary mode of action of fenofibric acid is through the activation of the nuclear transcription factor PPARa, predominantly expressed in tissues that metabolize fatty acids, such as the liver, kidney, heart, and muscle.On activation by binding of the fibrate, PPARa binds as heterodimers with retinoid X receptor (RXR), which subsequently recognizes and binds to specific PPARa-response elements leading to modulation of expression of the target genes. In particular, the activity of lipoprotein lipase is increased and synthesis of apoprotein C-III is decreased, which together enhance the clearance of circulating TG-rich lipoproteins. The resulting fall in TG produces an alteration in the size and composition of LDL from small dense particles to large buoyant particles. These larger particles have a greater affinity for cholesterol receptors and are catabolized rapidly. Choline fenofibriate acid is contraindicated in patients with severe renal impairment.
• Uses: A new formulation of fenofibric acid, ABT-335, co-administered with statins. A new formulation of fenofibric acid, ABT-335,

Technology Process of Unii-4bmh7izt98

There total 6 articles about Unii-4bmh7izt98 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

fenofibrate (49562-28-9) + cholin hydroxide (123-41-1) → choline fenofibrate (856676-23-8)

Guidance literature:

In ethanol; at 80 ℃; for 5h; Solvent; Large scale;

Reference yield: 75.0%

fenofibric acid (42017-89-0) + choline chloride (67-48-1) → choline fenofibrate (856676-23-8)

Guidance literature:

fenofibric acid; With triethylamine; In ethanol;

choline chloride; In ethanol; Reflux;

Reference yield: 70.0%

ethyl 2-bromoisobutyrate (600-00-0) + 4-chloro-4'-hydroxybenzophenone (42019-78-3) + cholin hydroxide (123-41-1) → choline fenofibrate (856676-23-8)

Guidance literature:

ethyl 2-bromoisobutyrate; 4-chloro-4'-hydroxybenzophenone; With potassium carbonate; at 145 ℃; for 3h;

cholin hydroxide; In propan-1-ol; water; for 3h; Heating / reflux;

upstream raw materials:

ethyl 2-bromoisobutyrate

4-chloro-4'-hydroxybenzophenone

cholin hydroxide

isopropyl 2-bromo-2?methylpropanoate

Refernces

• 1、 -. "Preparation method of choline fenofibrate". Paragraph 0068; 0069. . Retrieved 2019/03/08.
• 2、 -. "PROCESS FOR THE PREPARATION OF CHOLINE SALT OF FENOFIBRIC ACID AND ITS NOVEL POLYMORPH". Page/Page column 3. . Retrieved 2011/12/12.