3-Aminocyclobutanone hydrochloride

Base Information

• Chemical Name: 3-Aminocyclobutanone hydrochloride
• CAS No.: 1035374-20-9
• Molecular Formula: C4H8ClNO
• Molecular Weight: 121.567
• Hs Code.: 2922399090
• Mol file: 1035374-20-9.mol

Synonyms:3-Aminocyclobutanone hydrochloride (1:1);

Chemical Property of 3-Aminocyclobutanone hydrochloride

Chemical Property:

• Melting Point: 127-130 °C (decomp)
• PSA: 43.09000
• LogP: 1.17890
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

3-Aminocyclobutanonehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Aminocyclobutanone is used to prepare aminocyclopentenyl- and aminocyclobutylphosphinic acids as γ-aminobutyric acid ρ1 receptor antagonists. It is also used to prepare pyrrolopyrazine derivs. as selective spleen tyrosine kinase inhibitors.

Technology Process of 3-Aminocyclobutanone hydrochloride

There total 3 articles about 3-Aminocyclobutanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.8%

3-oxocyclobutane-1-carbonyl chloride (130233-77-1) → 3-aminocyclobutan-1-one hydrochloride (1035374-20-9)

Guidance literature:

3-oxocyclobutane-1-carbonyl chloride; With sodium azide; In water; at 0 - 20 ℃; for 2h;

With hydrogenchloride; In water; at 90 ℃; for 18h;

Reference yield:

3-(tert-butyloxycarbonylamino)cyclobutan-1-one (154748-49-9) → 3-aminocyclobutan-1-one hydrochloride (1035374-20-9)

Guidance literature:

With hydrogenchloride; In dichloromethane; ethyl acetate; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

C5H5N3O2 → 3-aminocyclobutan-1-one hydrochloride (1035374-20-9)

Guidance literature:

C₅H₅N₃O₂; In benzene; at 60 ℃;

With hydrogenchloride; In water; benzene; at 90 ℃;

DOI:10.1021/jm7015842

upstream raw materials:

3-(tert-butyloxycarbonylamino)cyclobutan-1-one

3-oxocyclobutane-1-carbonyl chloride

Downstream raw materials:

3-(tert-butyloxycarbonylamino)cyclobutan-1-one

tert-butyl (7-(3-fluorophenyl)-4-((3-oxocyclobutyl)carbamoyl)isoquinolin-1-yl)carbamate

Refernces

• 1、 -. "N-ACYLETHANOLAMINE HYDROLYZING ACID AMIDASE (NAAA) INHIBITORS AND THEIR USE THEREOF". Paragraph 0178. . Retrieved 2015/12/08.
• 2、 Kumar, Rohan J.,Chebib, Mary,Hibbs, David E.,Kim, Hye-Lim,Johnston, Graham A. R.,Salam, Noeris K.,Hanrahan, Jane R.. "Novel γ-aminobutyric acid ρ1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships". experimental part. p. 3825 - 3840. Retrieved 2009/04/07.