154748-49-9

Basic information

• Product Name: Carbamic acid, (3-oxocyclobutyl)-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, (3-oxocyclobutyl)-, 1,1-dimethylethyl ester (9CI);3-OXOCYCLOBUTYLCARBAMIC ACID, 1,1-DIMETHYLETHYL ESTER;3-(tert-Butyloxycarbonylamino)cyclobutan-1-one;(3-Oxo-cyclobutyl)-carbamic acid tert-butyl ester;Tert-butyl3-oxocyclobutylcarbamate;tert-butyl 3-oxocyclobuty...;CarbaMic acid, N-(3-oxocyclobutyl)-, 1,1-diMethylethyl ester;3-(Boc-amino)cyclobutanone
• CAS NO: 154748-49-9
• Molecular Formula: C9H15NO3
• Molecular Weight: 185.2203
• EINECS: 2017-001-1
• Product Categories: N-BOC;Amines;Building Blocks;C8 to C9;C9;Chemical Synthesis;Ethers;New Products for Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Oxygen Compounds
• Mol File: 154748-49-9.mol
• Article Data: 33

Chemical Properties

• Melting Point: 120-125℃
• Boiling Point: 302.1 °C at 760 mmHg
• Flash Point: 136.5 °C
• Appearance: /
• Density: 1.1 g/cm³
• Vapor Pressure: 0.00101mmHg at 25°C
• Refractive Index: 1.474
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.60±0.20(Predicted)
• CAS DataBase Reference: Carbamic acid, (3-oxocyclobutyl)-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (3-oxocyclobutyl)-, 1,1-dimethylethyl ester (9CI)(154748-49-9)
• EPA Substance Registry System: Carbamic acid, (3-oxocyclobutyl)-, 1,1-dimethylethyl ester (9CI)(154748-49-9)

Safety Data

• Statements: 52-51/53-36/37/38
• Safety Statements: 3/9-4-22-26-28-29-35-44
• RIDADR: 3077
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 154748-49-9(Hazardous Substances Data)

Usage

Form

Solid

Uses

tert-Butyl (3-Oxocyclobutyl)carbamate is used in the preparation of 5-HT1-like receptor agonists. It is also used to synthesize (oxadiazolyl)quinoline derivatives as highly potent HCV NS4B inhibitors.

InChI:InChI=1/C9H15NO3/c1-9(2,3)13-8(12)10-6-4-7(11)5-6/h6H,4-5H2,1-3H3,(H,10,12)

Upstream product

• 7150-72-3 t-butyl N-vinylcarbamate 
• 4640-43-1 N-3-aminocyclobutan-1-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 130233-77-1 3-oxocyclobutane-1-carbonyl chloride 
• 23761-23-1 3-oxocyclobutanecarboxylic acid 
• 75-65-0 tert-butyl alcohol 
• 1035374-20-9 3-aminocyclobutan-1-one hydrochloride 
• 130369-04-9 (3-methylene-cyclobutyl)-carbamic acid tert-butyl ester 

Downstream Products

• 389890-43-1 tert-butyl (1,3-cis)-N-(3-hydroxycyclobutyl)carbamate 
• 1029720-19-1 tert-butyl (3,3-difluorocyclobutyl)carbamate 
• 1355328-30-1 N-(3,3-difluorocyclobutyl)formamide 
• 1448348-04-6 (4S)-N-(1-(2-Chlorophenyl)-2-(3,3-difluorocyclobutylamino)-2-oxoethyl)-N-(3-fluoro-phenyl)-2-oxooxazolidine-4-carboxamide 
• 1448345-75-2 (S)-N-((R)-1-(2-chlorophenyl)-2-(3,3-difluorocyclobutylamino)-2-oxoethyl)-N-(3-fluorophenyl)-2-oxo-3-(pyrimidin-2-yl)oxazolidine-4-carboxamide 
• 1448348-05-7 (S)-N-(1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(3-fluoro-phenyl)-6-oxopiperidine-2-carboxamide 
• 1448348-25-1 (S)-N-((S)-1-( 2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(3-fluorophenyl)-5-oxomorpholine-3-carboxamide 
• 1448346-14-2 (S)-N-((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(3-fluorophenyl)-5-oxo-4-(pyrimidin-2-yl)morpholine-3-carboxamide 
• 1448348-39-7 5-((2S)-N-(1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyano pyridin-2-yl)-5-oxopyrrolidine-2-carboxamido)isophthalamide 
• 1448347-64-5 (2S)-N-(1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(3,5-dicyanophenyl)-5-oxopyrrolidine-2-carboxamide 
• 1448348-13-7 (2S)-4-(tert-Butyldimethylsilyloxy)-N-(1-(2-chlorophenyl)-2-(3,3-difluorocyclobut-ylamino)-2-oxoethyl)-N-(3-fluorophenyl)-4-methyl-5-oxopyrrolidine-2-carboxamide 
• 1448348-14-8 (2S)-4-(tert-Butyldimethylsilyloxy)-N-(1-(2-chlorophenyl)-2-(3,3-difluorocyclobutyl-amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(3-fluorophenyl)-4-methyl-5-oxopyrrolidine-2-carboxamide 
• 1284249-30-4 tert-butyl 3-fluorocyclobutylcarbamate 
• 130369-04-9 (3-methylene-cyclobutyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Preparation method of tert-butyl 3-oxocyclobutyl carbamate

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