N-methyl-N-nosyl-L-isoleucine phenacyl ester

Base Information

• Chemical Name: N-methyl-N-nosyl-L-isoleucine phenacyl ester
• CAS No.: 1208119-61-2
• Molecular Formula: C₂₁H₂₄N₂O₇S
• Molecular Weight: 448.497
• Mol file: 1208119-61-2.mol

Synonyms:

Chemical Property of N-methyl-N-nosyl-L-isoleucine phenacyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-methyl-N-nosyl-L-isoleucine phenacyl ester

There total 1 articles about N-methyl-N-nosyl-L-isoleucine phenacyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + N-nosyl-L-isoleucine phenacyl ester (1208119-60-1) → N-methyl-N-nosyl-L-isoleucine phenacyl ester (1208119-61-2)

Guidance literature:

In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo901643f

Reference yield: 70.0%

N-methyl-N-nosyl-L-isoleucine phenacyl ester (1208119-61-2) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → N-Fmoc-N-methyl-L-isoleucine (138775-22-1,1356090-81-7)

Guidance literature:

N-methyl-N-nosyl-L-isoleucine phenacyl ester; With sodium thiophenolate; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

With sodium carbonate; In water; pH=9;

(fluorenylmethoxy)carbonyl chloride; In 1,4-dioxane; at 0 ℃;

DOI:10.1021/jo901643f

upstream raw materials:

diazomethane

N-nosyl-L-isoleucine phenacyl ester

Downstream raw materials:

N-Fmoc-N-methyl-L-isoleucine

Refernces