Technology Process of (+/-)-desdimethoxymesembrine
There total 5 articles about (+/-)-desdimethoxymesembrine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) lithium N-cyclohexyl-N-isopropylamide / 1.) -78 deg C, 1 h, then over 1 h 10 deg C, THF, 2.) room temp. overnight
2: diisobutylaluminum hydride / hexane; tetrahydrofuran
3: Stevens annelation
With
diisobutylaluminium hydride; lithium cyclohexylisopropylamide;
In
tetrahydrofuran; hexane;
DOI:10.1016/S0040-4039(00)94007-3
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) lithium N-cyclohexyl-N-isopropylamide / 1.) -78 deg C, 1 h, then over 1 h 10 deg C, THF, 2.) room temp. overnight
2: diisobutylaluminum hydride / hexane; tetrahydrofuran
3: Stevens annelation
With
diisobutylaluminium hydride; lithium cyclohexylisopropylamide;
In
tetrahydrofuran; hexane;
DOI:10.1016/S0040-4039(00)94007-3
- Guidance literature:
-
Multi-step reaction with 2 steps
1: diisobutylaluminum hydride / hexane; tetrahydrofuran
2: Stevens annelation
With
diisobutylaluminium hydride;
In
tetrahydrofuran; hexane;
DOI:10.1016/S0040-4039(00)94007-3