Technology Process of 4-bromo-2-(bromomethyl)pyridine hydrobromide
There total 3 articles about 4-bromo-2-(bromomethyl)pyridine hydrobromide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-bromo-2-(hydroxymethyl)pyridine;
With
phosphorus tribromide;
In
chloroform;
at 0 ℃;
Reflux;
With
potassium carbonate;
In
dichloromethane; water;
Cooling with ice;
With
hydrogen bromide; acetic acid;
In
diethyl ether;
DOI:10.1016/j.tet.2009.07.013
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dichloromethane / 12 h / 0 °C / Reflux
2: phosphorus tribromide / dichloromethane / 18 h / 0 °C / Reflux
With
phosphorus tribromide;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C
2: dichloromethane / 12 h / 0 °C / Reflux
3: phosphorus tribromide / dichloromethane / 18 h / 0 °C / Reflux
With
phosphorus tribromide; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
