22282-99-1

Basic information

• Product Name: 4-Bromo-2-methylpyridine
• Synonyms: CHEMBRDG-BB 4014101;2-METHYL-4-BROMOPYRIDINE;4-BROMO-2-METHYLPYRIDINE;4-BROMO-2-METHYL-PYRIDINE HYDROCHLORIDE;4-BROMO-2-METHYL-PYRIDINIUM, CHLORIDE;4-BROMO-2-PICOLINE;4-BROMO-2-PICOLINE HCL;4-BROMO-METHYL-PYRIDINE
• CAS NO: 22282-99-1
• Molecular Formula: C₆H₆BrN
• Molecular Weight: 172.02
• EINECS: -0
• Product Categories: Pyridine;Halides;Heterocycles;Pyridine Series;Pyridines, Pyrimidines, Purines and Pteredines;Heterocyclic Series;pharmacetical;Pyridines;Organohalides;Aromatics Compounds;Bromopyridines;Halopyridines;Aromatics;Boronic Acid;Building Blocks;C5 to C6;C6 to C7;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 22282-99-1.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 76 °C / 14mmHg
• Flash Point: 174 °F
• Appearance: Light yellow liquid
• Density: 1.450 g/mL at 25 °C
• Vapor Pressure: 0.581mmHg at 25°C
• Refractive Index: n 20/D 1.556
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Dichloromethane
• PKA: 4.38±0.10(Predicted)
• Water Solubility: Miscible with dichloromethane. Immiscible with water.
• CAS DataBase Reference: 4-Bromo-2-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-methylpyridine(22282-99-1)
• EPA Substance Registry System: 4-Bromo-2-methylpyridine(22282-99-1)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41-36/37/38-20/21/22
• Safety Statements: 26-36/39-36
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 22282-99-1(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow liquid

Uses

Different sources of media describe the Uses of 22282-99-1 differently. You can refer to the following data:
1. 4-Bromo-2-methylpyridine is a starting material used in a synthesis of crown-ester-bipyridines and viologens via sodium or nickel reductive coupling, side chain oxidation and esterification.
2. Used in the preparation of phenyloxadiazolyl pyridines as immunomodulating agents.
3. 4-Bromo-2-methylpyridine is used as a starting material in the preparation of crown-ester-bipyridines and viologens through sodium or nickel reductive coupling, side chain oxidation and esterification. Further, it serves as an important raw material and intermediate in organic synthesis, pharmaceuticals, agrochemicals and in dyes.

InChI:InChI=1/C6H6BrN/c1-5-4-6(7)2-3-8-5/h2-4H,1H3

Upstream product

• 18437-58-6 3-methyl-4-pyridinamine 
• 13508-96-8 2-methyl-4-nitro-pyridine 
• 506-96-7 Acetyl bromide 
• 67-66-3 chloroform 
• 7789-60-8 phosphorus tribromide 
• 19524-06-2 4-bromopyridine hydrochloride 
• 931-19-1 2-methylpyridine N-oxide 
• 58530-53-3 2,4-dibromopyridine 
• 74-88-4 methyl iodide 
• 23056-36-2 2-chloro-4-nitropyridine 
• 676-58-4 methylmagnesium chloride 
• 131747-63-2 4-bromo-2-pyridinecarboxaldehyde 
• 75-16-1 methylmagnesium bromide 
• 5470-66-6 2-methyl-4-nitropyridine N-oxide 

Downstream Products

• 131747-63-2 4-bromo-2-pyridinecarboxaldehyde 
• 131747-45-0 4-bromo-2-(hydroxymethyl)pyridine 
• 108337-74-2 2,6-dimethyl-4-(4-bromo-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester 
• 94413-70-4 1-(2-methylpyridin-4-yl)methanamine 
• 1109216-90-1 C₁₅H₁₄Cl₂N₂O₂ 
• 579476-63-4 2-methylpyridine-4-boronic acid 
• 1276655-91-4 2-methyl-4-(4-(trifluoromethyl)phenyl)pyridine hydrochloride 
• 16830-24-3 methyl 2-methylisonicotinate 
• 1276680-78-4 1-{3-(4-fluorophenyl)-7-[4-(1-hydroxy-1-trifluoromethylpropyl)[1,2,3]triazol-1-ylmethyl]indolizin-2-yl}ethanone 
• 1276680-77-3 3-(4-fluorophenyl)-7-[4-(1-hydroxy-1-trifluoromethylpropyl)[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid methoxymethylamide 
• 1276680-76-2 3-(4-fluorophenyl)-7-[4-(1-hydroxy-1-trifluoromethylpropyl)[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid 
• 1276680-74-0 3-(4-fluorophenyl)-7-formylindolizine-2-carboxylic acid ethyl ester 
• 1276680-73-9 3-(4-fluorophenyl)-7-{[5-(1-hydroxy-1-trifluoromethylpropyl)[1,3,4]oxadiazol-2-ylamino]methyl}indolizine-2-carboxylic acid ethyl ester 
• 1276680-64-8 3-(4-fluorophenyl)-7-[4-(1-hydroxy-1-trifluoromethylpropyl)[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis of atropisomeric 1,8-bis(4′,4′-dipyridyl)naphthalenes from 4-trimethylstannylpyridines

Two synthetic strategies towards atropisomeric 2′,2′-disubstituted 1,8-bis(4′,4′-dipyridyl)naphthalenes using Stille crosscoupling of trimethylstannylpyridine derivatives and 1,8-di-iodonaphthalene have been investigated. Introduction of substituents into the pyridyl moieties prior to the cross-coupling step provides higher overall yields than derivatization of 1,8-bis(4′,4′-dipyridyl)naphthalene under Ziegler reaction conditions.

NOVEL ORGANIC COMPOUND AND MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES COMPRISING THE SAME AND ORGANIC ELECTROLUMINESCENT DEVICES COMPRISING THE SAME

The present invention provides a novel organic compound represented by chemical formula 1, a material for an organic electroluminescent device including the organic compound, and an organic electroluminescent device. The present invention can improve color purity and device life.

A 2 - methyl -4 - bromo pyridine preparation method

The invention belongs to the field of organic synthesis, in particular relates to a 2 - methyl - 4 - bromo pyridine method, comprises the following steps: (1) malonic acid diethyl ester and alkali metal reaction to produce salt, then dropwise 2 - chloro - 4 - nitro pyridine to a toluene solution of a condensation reaction, after decarboxylation under acidic conditions shall be 2 - methyl - 4 nitro pyridine; (2) 2 - methyl - 4 - nitro-pyridine in under the catalysis of the Pd/C, methanol as the solvent, hydrogen reduction, filtered, the filtrate is concentrated, shall be 2 - methyl - 4 - aminopyridine; (3) 2 - methyl - 4 - aminopyridine first with an acid generating salt, cooled to - 10 °C - 0 °C, [...], drops the instillment sodium nitrite aqueous solution, pH adjusting solution is dropped is alkaline, and then extracted, drying, concentration, shall be 2 - methyl - 4 - bromo pyridine. The beneficial effect of the invention is: mild reaction conditions, is easy to operate, after treatment is simple, and easy to enlarge production, is extremely suitable for industrial production; good catalytic effect, high yield; low prices of raw materials, the production cost is low.