4-chloro-2,3,5,6-tetrafluorobenzoyl fluoride

Base Information

• Chemical Name: 4-chloro-2,3,5,6-tetrafluorobenzoyl fluoride
• CAS No.: 145588-26-7
• Molecular Formula: C₇ClF₅O
• Molecular Weight: 230.521
• Mol file: 145588-26-7.mol

Synonyms:

Chemical Property of 4-chloro-2,3,5,6-tetrafluorobenzoyl fluoride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-2,3,5,6-tetrafluorobenzoyl fluoride

There total 4 articles about 4-chloro-2,3,5,6-tetrafluorobenzoyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-2,3,5,6-tetrafluorobenzoyl chloride (145572-10-7) → 4-chloro-2,3,5,6-tetrafluorobenzoyl fluoride (145588-26-7)

Guidance literature:

With tetraphenylphosphonium bromide; sodium fluoride; In various solvent(s); at 155 ℃; for 10h;

DOI:10.1016/S0022-1139(00)80200-6

Reference yield:

Pentafluorobenzoic acid (602-94-8) → 4-chloro-2,3,5,6-tetrafluorobenzoyl fluoride (145588-26-7)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. NaOH, NaHS / 2 h / 70 °C

2: 978 mg / 30percent H₂O₂, AcOH / 2 h / 70 °C

3: SOCl₂, DMF / 6 h / Heating

4: NaF, Ph₄PBr / various solvent(s) / 10 h / 155 °C

With sodium hydroxide; sodium hydrogensulfide; thionyl chloride; dihydrogen peroxide; tetraphenylphosphonium bromide; sodium fluoride; acetic acid; N,N-dimethyl-formamide; In various solvent(s);

DOI:10.1016/S0022-1139(00)80200-6

Reference yield:

2,3,5,6-tetrafluoro-4-mercapto-benzoic acid (5211-44-9) → 4-chloro-2,3,5,6-tetrafluorobenzoyl fluoride (145588-26-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 978 mg / 30percent H₂O₂, AcOH / 2 h / 70 °C

2: SOCl₂, DMF / 6 h / Heating

3: NaF, Ph₄PBr / various solvent(s) / 10 h / 155 °C

With thionyl chloride; dihydrogen peroxide; tetraphenylphosphonium bromide; sodium fluoride; acetic acid; N,N-dimethyl-formamide; In various solvent(s);

DOI:10.1016/S0022-1139(00)80200-6

upstream raw materials:

4-chloro-2,3,5,6-tetrafluorobenzoyl chloride

Pentafluorobenzoic acid

2,3,5,6-tetrafluoro-4-mercapto-benzoic acid

4-sulpho-2,3,5,6-tetrafluorobenzoic acid

Downstream raw materials:

4-chloro-2,3,5,6-tetrafluoro-N-benzanilide

methyl 4-chloro-2,3,5,6-tetrafluorobenzoate

Refernces