ethyl rac-2-amino-3-(2-chloro-5-nitrophenyl)propionate

Base Information

• Chemical Name: ethyl rac-2-amino-3-(2-chloro-5-nitrophenyl)propionate
• CAS No.: 603945-47-7
• Molecular Formula: C₁₁H₁₃ClN₂O₄
• Molecular Weight: 272.688
• Mol file: 603945-47-7.mol

Synonyms:

Chemical Property of ethyl rac-2-amino-3-(2-chloro-5-nitrophenyl)propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl rac-2-amino-3-(2-chloro-5-nitrophenyl)propionate

There total 1 articles about ethyl rac-2-amino-3-(2-chloro-5-nitrophenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl N-diphenylmethylene glycine (69555-14-2) + 1-chloro-2-(chloromethyl)-4-nitrobenzene (69422-57-7) → ethyl rac-2-amino-3-(2-chloro-5-nitrophenyl)propionate (603945-47-7)

Guidance literature:

With tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; water;

DOI:10.1002/chem.201200990

Reference yield:

ethyl rac-2-amino-3-(2-chloro-5-nitrophenyl)propionate (603945-47-7) → ethyl rac-2-amino-3-(2-chloro-5-nitrophenyl)propionate hydrochloride (1402454-77-6)

Guidance literature:

With hydrogenchloride; In water; acetone;

DOI:10.1002/chem.201200990

Reference yield:

ethyl rac-2-amino-3-(2-chloro-5-nitrophenyl)propionate (603945-47-7) → rac-2-amino-3-(2-chloro-5-nitrophenyl)propionic acid hydrochloride (1402454-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water; acetone

2: hydrogenchloride / water / Reflux

With hydrogenchloride; In water; acetone;

DOI:10.1002/chem.201200990

upstream raw materials:

ethyl N-diphenylmethylene glycine

1-chloro-2-(chloromethyl)-4-nitrobenzene

Downstream raw materials:

ethyl rac-2-amino-3-(2-chloro-5-nitrophenyl)propionate hydrochloride

rac-2-amino-3-(2-chloro-5-nitrophenyl)propionic acid hydrochloride

ethyl (R)-2-amino-3-(2-chloro-5-nitrophenyl)propionate

(S)-2-amino-3-(2-chloro-5-nitrophenyl)propionic acid

Refernces