N-(2-amino-2-oxoethyl)-3,5-dimethyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxamide

Base Information

• Chemical Name: N-(2-amino-2-oxoethyl)-3,5-dimethyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxamide
• CAS No.: 1313197-53-3
• Molecular Formula: C₂₄H₂₁F₃N₄O₃
• Molecular Weight: 470.451
• Mol file: 1313197-53-3.mol

Synonyms:

Chemical Property of N-(2-amino-2-oxoethyl)-3,5-dimethyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-amino-2-oxoethyl)-3,5-dimethyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxamide

There total 6 articles about N-(2-amino-2-oxoethyl)-3,5-dimethyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone (2003-10-3) → N-(2-amino-2-oxoethyl)-3,5-dimethyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxamide (1313197-53-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium carbonate / acetonitrile / 16 h / Reflux

2.1: hydrazine hydrate / ethylene glycol / 2 h / 130 °C

2.2: 2 h / 160 °C

3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 85 °C / Inert atmosphere

4.1: pyridine / copper(II) acetate monohydrate / 55 °C

5.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 3 h / 85 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.08 h / 10 - 35 °C

With pyridine; water; potassium acetate; potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper(II) acetate monohydrate; In tetrahydrofuran; ethanol; ethylene glycol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

(4-bromo-1-benzofuran-2-yl)[3-(trifluoromethyl)phenyl]methanone (1207969-02-5) → N-(2-amino-2-oxoethyl)-3,5-dimethyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxamide (1313197-53-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrazine hydrate / ethylene glycol / 2 h / 130 °C

1.2: 2 h / 160 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 85 °C / Inert atmosphere

3.1: pyridine / copper(II) acetate monohydrate / 55 °C

4.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 3 h / 85 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.08 h / 10 - 35 °C

With pyridine; water; potassium acetate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper(II) acetate monohydrate; In tetrahydrofuran; ethanol; ethylene glycol; N,N-dimethyl-formamide;

Reference yield:

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[3-(trifluoromethyl)benzyl]-1-benzofuran (1207969-15-0) → N-(2-amino-2-oxoethyl)-3,5-dimethyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxamide (1313197-53-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / copper(II) acetate monohydrate / 55 °C

2: sodium hydroxide; water / ethanol; tetrahydrofuran / 3 h / 85 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.08 h / 10 - 35 °C

With pyridine; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; copper(II) acetate monohydrate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

upstream raw materials:

ethyl 3,5-dimethyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzofuran-4-yl]-1H-pyrazole-4-carboxylate

2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone

2-bromo-6-hydroxybenzaldehyde

(4-bromo-1-benzofuran-2-yl)[3-(trifluoromethyl)phenyl]methanone

Refernces