Multi-step reaction with 8 steps
1: 68 percent / TEA / dimethylformamide / 72 h
2: H2, HCl / Pd/C / dimethylformamide
3: 1.) TEA, IBC, 2.) TEA / 1.) CH2Cl2, -20 deg C, 10 min, 2.) CH2Cl2-DMF
4: H2, HCl / Pd/C / dimethylformamide
5: TEA / dimethylformamide / 72 h / Ambient temperature
6: H2, HCl / Pd/C / dimethylformamide
7: 1.) TEA, IBC, 2.) TEA / 1.) CH2Cl2, -20 deg C, 15 min, 2.) CH2Cl2-DMF
8: H2, HCl / Pd/C / dimethylformamide; dioxane / 16 h
With
hydrogenchloride; 2-methylpropyl cyanoacrylate; TEA; hydrogen;
palladium on activated charcoal;
In
1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)98916-1