2-nitro-3-pivaloylmethyltoluene

Base Information

• Chemical Name: 2-nitro-3-pivaloylmethyltoluene
• CAS No.: 886841-16-3
• Molecular Formula: C₁₃H₁₇NO₄
• Molecular Weight: 251.282
• Mol file: 886841-16-3.mol

Synonyms:

Chemical Property of 2-nitro-3-pivaloylmethyltoluene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-nitro-3-pivaloylmethyltoluene

There total 2 articles about 2-nitro-3-pivaloylmethyltoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

pivaloyl chloride (3282-30-2) + 2-methyl-6-hydroxymethyl-1-nitrobenzene (80866-76-8) → 2-nitro-3-pivaloylmethyltoluene (886841-16-3)

Guidance literature:

With pyridine; for 3h; Heating;

DOI:10.1080/00397910500503470

Reference yield:

2-(3-methyl-2-nitrophenyl)acetic acid (18710-86-6) → 2-nitro-3-pivaloylmethyltoluene (886841-16-3)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorotrimethylsilane; benzyltriethylammonium borohydride / CH₂Cl₂ / 24 h / 20 °C

2: 99 percent / pyridine / 3 h / Heating

With pyridine; chloro-trimethyl-silane; Benzyltriethylammonium borohydride; In dichloromethane;

DOI:10.1080/00397910500503470

Reference yield:

2-nitro-3-pivaloylmethyltoluene (886841-16-3) → indole-7-methanol (1074-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / 4 h / 130 °C

2: 39 percent / hydrazine hydrate; Raney nickel / tetrahydrofuran; methanol / 6 h / 20 °C

With nickel; hydrazine hydrate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1080/00397910500503470

upstream raw materials:

pivaloyl chloride

2-methyl-6-hydroxymethyl-1-nitrobenzene

2-(3-methyl-2-nitrophenyl)acetic acid

Downstream raw materials:

1H-indole-7-carbaldehyde

indole-7-methanol

Refernces