18710-86-6

Basic information

• Product Name: 2-nitro-3-Methyl-benzeneacetic acid
• Synonyms: 2-nitro-3-Methyl-benzeneacetic acid;Benzeneacetic acid, 3-Methyl-2-nitro-;2-(3-Methyl-2-nitrophenyl)acetic acid
• CAS NO: 18710-86-6
• Molecular Formula: C₉H₉NO₄
• Molecular Weight: 195.17206
• Mol File: 18710-86-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 154-155℃
• Boiling Point: 348.1±27.0 °C(Predicted)
• Appearance: /
• Density: 1.346±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.95±0.10(Predicted)
• CAS DataBase Reference: 2-nitro-3-Methyl-benzeneacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-nitro-3-Methyl-benzeneacetic acid(18710-86-6)
• EPA Substance Registry System: 2-nitro-3-Methyl-benzeneacetic acid(18710-86-6)

Safety Data

• Hazardous Substances Data: 18710-86-6(Hazardous Substances Data)

Usage

General Description

2-nitro-3-Methyl-benzeneacetic acid, also known as Diclofenac, is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to reduce inflammation and pain. It is a derivative of acetic acid and has both analgesic and anti-inflammatory properties. Diclofenac works by inhibiting the synthesis of prostaglandins, which are compounds that promote inflammation, pain, and fever. It is often prescribed to treat conditions such as arthritis, menstrual cramps, and acute pain. Additionally, Diclofenac is available in various forms, including oral tablets, topical gels, and injectable solutions, making it a versatile option for pain management. However, it is important to use this medication as directed by a healthcare professional, as misuse can lead to serious side effects and complications.

Upstream product

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Downstream Products

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Relevant articles and documents

Pendant Alkoxy Groups on N-Aryl Substitutions Drive the Efficiency of Imidazolylidene Catalysts for Homoenolate Annulation from Enal and Aldehyde

Hydrogen-transfer in the tetrahedral intermediate generated from an imidazolylidene catalyst and α,β-unsaturated aldehyde forms a conjugated Breslow intermediate. This is a critical step affecting the efficiency of the NHC-catalyzed γ-butyrolactone formation via homoenolate addition to aryl aldehydes. A novel type of imidazolylidene catalyst with pendant alkoxy groups on the ortho-N-aryl groups is described. Catalyst of this sort facilitates the formation of the conjugated Breslow intermediate. Studies of the rate constants for homoenolate annulation affording γ-butyrolactones, reveal that introduction of the oxygen atoms in the appropriate position of the N-aryl substituents can increase the efficiency of imidazolylidene catalysts. Structural and mechanistic studies revealed that pendant alkoxy groups can be located close to the proton of the tetrahedral intermediate, thereby facilitating the proton transfer.

PHENYLALKYL AND PYRIDYLALKYL PIPERAZINE DERIVATIVES

This invention relates to compounds of the formula (1) wherein R1, R3, R4, X1, and X2 are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system and other disorders.