hydrocortisol

Base Information

• Chemical Name: hydrocortisol
• CAS No.: 16355-27-4
• Molecular Formula: C₂₁H₃₂O₅
• Molecular Weight: 364.482
• Mol file: 16355-27-4.mol

Synonyms:

Chemical Property of hydrocortisol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of hydrocortisol

There total 11 articles about hydrocortisol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.6%

17α-21-dihydroxy-5-α-pregnane-3,20-dione (312-99-2) → 11α,17α,21-trihydroxy-5α-pregnane-3,20-dione (516-41-6,1482-50-4,16355-27-4,127182-47-2,71973-95-0)

Guidance literature:

C_. blakesleea culture;

DOI:10.1007/BF00764822

Reference yield:

HYDROCORTISONE (50-23-7) → hydrocortisol (16355-27-4,71973-95-0)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In N,N-dimethyl-formamide; for 12h; under 2585.81 Torr;

Reference yield:

21-acetoxy-17α-hydroxy-5α-pregnane-3,20-dione (1639-45-8) → 11α,17α,21-trihydroxy-5α-pregnane-3,20-dione (516-41-6,1482-50-4,16355-27-4,127182-47-2,71973-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / KOH / methanol / 1 h

2: 69.6 percent / C_. blakesleea culture

With potassium hydroxide; In methanol;

DOI:10.1007/BF00764822

upstream raw materials:

17α-21-dihydroxy-5-α-pregnane-3,20-dione

21-acetoxy-17α-hydroxy-5α-pregnane-3,20-dione

HYDROCORTISONE

Refernces

• 1、 -. "synthetic bile acid preparation". Paragraph 0094-0098. . Retrieved 2015/09/28.